INT241243

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Context Info
Confidence 0.77
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 30
Total Number 30
Disease Relevance 9.05
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Pkd2) transport (Pkd2) endoplasmic reticulum (Pkd2)
plasma membrane (Pkd2) cilium (Pkd2) transmembrane transport (Pkd2)
Anatomy Link Frequency
oocytes 4
cilia 1
reticulum 1
FRT 1
Pkd2 (Mus musculus)
Pain Link Frequency Relevance Heat
Mechanosensation 56 98.16 Very High Very High Very High
TRP channel 113 96.04 Very High Very High Very High
imagery 153 95.92 Very High Very High Very High
Mechanotransduction 7 65.60 Quite High
metalloproteinase 7 64.72 Quite High
fibrosis 16 54.52 Quite High
Cholecystokinin 7 42.96 Quite Low
Thermal hyperalgesia 14 17.36 Low Low
Inflammation 16 16.20 Low Low
tail-flick 14 13.28 Low Low
Disease Link Frequency Relevance Heat
Autosomal Dominant Polycystic Kidney 132 99.48 Very High Very High Very High
Pressure And Volume Under Development 106 98.84 Very High Very High Very High
Adhesions 133 98.40 Very High Very High Very High
Disease 256 95.60 Very High Very High Very High
Cyst 291 95.08 Very High Very High Very High
Targeted Disruption 107 94.92 High High
Stress 60 94.44 High High
Polycystic Kidney Disease 544 91.60 High High
Pancreatic Cyst 7 89.68 High High
Apoptosis 121 87.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, coexpression of TRPV4 significantly increased TRPP2 surface expression (Fig. 2 G), whereas TRPP2 reduced both TRPV4 surface expression and TRPV4 total protein levels (Fig. 2 I).
Gene_expression (expression) of TRPP2
1) Confidence 0.77 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.28 Pain Relevance 0.03
Thus, transiently expressed TRPP2 appears not to localize efficiently at the surface of HEK 293T cells.
Gene_expression (expressed) of TRPP2
2) Confidence 0.77 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0 Pain Relevance 0
Because a carboxy-terminal acidic cluster precludes the expression of TRPP2 at the cell surface (Köttgen et al., 2005), only TRPV4, but not TRPP2, raised the steady-state inward currents in X. laevis oocytes.
Gene_expression (expression) of TRPP2 in oocytes
3) Confidence 0.77 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.39 Pain Relevance 0
Similarly, a V5 tag was engineered into the second extracellular loop of human TRPP2 (TRPP2-V5 loop; in the cdm8 vector).
Gene_expression (loop) of TRPP2
4) Confidence 0.67 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.11 Pain Relevance 0.05
Because a carboxy-terminal acidic cluster precludes the expression of TRPP2 at the cell surface (Köttgen et al., 2005), only TRPV4, but not TRPP2, raised the steady-state inward currents in X. laevis oocytes.
Gene_expression (expression) of TRPP2 in oocytes
5) Confidence 0.67 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.41 Pain Relevance 0
Similarly, a V5 tag was engineered into the second extracellular loop of human TRPP2 (TRPP2-V5 loop; in the cdm8 vector).
Gene_expression (loop) of TRPP2
6) Confidence 0.67 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.11 Pain Relevance 0.05
In contrast to the TRPV4-V5 loop protein, expression of which stimulated efficient conversion of the AP substrate, the enzymatic reaction on cells expressing TRPP2-V5 loop protein resulted in a modest increase in the amount of AP product as compared with the mock-transfected cells (21% increase on average).
Gene_expression (expressing) of TRPP2
7) Confidence 0.67 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0 Pain Relevance 0
In brief, a loxP site was inserted in intron 10 of Pkd2 and a loxP-FRT-PGKneo-FRT cassette in intron 13 (Pkd2Tm1Tjw).
Gene_expression (cassette) of Pkd2 in FRT
8) Confidence 0.67 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.19 Pain Relevance 0
This effect was dramatically augmented in oocytes coexpressing TRPP2 (Fig. 2, E and F).
Gene_expression (coexpressing) of TRPP2 in oocytes
9) Confidence 0.60 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.43 Pain Relevance 0
Coexpression of TRPV4 and TRPP2 significantly augmented the swelling-activated currents in X. laevis oocytes, whereas steady-state currents remained unchanged (Fig. 2 A).
Gene_expression (Coexpression) of TRPP2 in oocytes associated with pressure and volume under development
10) Confidence 0.60 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.44 Pain Relevance 0
FRET

Carboxy-terminal fusions of TRPP2 with CFP and TRPV4 with YFP were coexpressed with a cDNA ratio of 1:3 (CFP/YFP) to minimize the probability of CFP-only multimers.

Gene_expression (coexpressed) of TRPP2
11) Confidence 0.60 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0 Pain Relevance 0
The current–voltage relationship revealed a slight outward rectification of the TRPV4 currents that was not substantially influenced by coexpression of TRPP2 (Fig. 2, C and D).
Gene_expression (coexpression) of TRPP2
12) Confidence 0.60 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.46 Pain Relevance 0
Because TRPP2 is expressed in nearly all tissues, our results point toward a mechanism by which TRPP2 promiscuously exploits other TRP channel members to exert tissue-specific functions.
Gene_expression (expressed) of TRPP2 associated with trp channel
13) Confidence 0.60 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.11 Pain Relevance 0.18
The following morpholinos were used: pkd2MO (5?
Gene_expression (used) of pkd2MO
14) Confidence 0.58 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0 Pain Relevance 0
On the other hand, polycystin-2 is mainly expressed in endoplasmic reticulum, where it functions as a Ca2+ release channel [45].
Gene_expression (expressed) of polycystin-2 in reticulum
15) Confidence 0.48 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.75 Pain Relevance 0
In contrast, expression of polycystin-2 seems to persist into adult life [62].
Gene_expression (expression) of polycystin-2
16) Confidence 0.48 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.57 Pain Relevance 0
Polycystin-1 (PC-1), polycystin-2 (PC-2) and other cystoproteins (not shown) are expressed in primary cilia, basal bodies or centrosomes.
Gene_expression (expressed) of polycystin-2 in cilia
17) Confidence 0.48 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.27 Pain Relevance 0.13
The PKD2 gene has 15 exons encoding ?
Gene_expression (gene) of PKD2
18) Confidence 0.42 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.42 Pain Relevance 0
The Pkd2?
Gene_expression (The) of Pkd2
19) Confidence 0.42 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 1.15 Pain Relevance 0
An interesting mouse model with a mutation in the Pkd2 gene (Pkd2?
Gene_expression (gene) of Pkd2
20) Confidence 0.42 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 1.00 Pain Relevance 0

General Comments

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