INT241244

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Context Info
Confidence 0.74
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.35
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Pkd2) transport (Pkd2) endoplasmic reticulum (Pkd2)
plasma membrane (Pkd2) cilium (Pkd2) transmembrane transport (Pkd2)
Anatomy Link Frequency
MDCK 1
FRT 1
Pkd2 (Mus musculus)
Pain Link Frequency Relevance Heat
TRP channel 32 84.84 Quite High
Mechanosensation 8 83.96 Quite High
qutenza 4 66.96 Quite High
tail-flick 4 10.48 Low Low
imagery 8 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Thermal hyperalgesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 16 95.92 Very High Very High Very High
Stress 12 79.88 Quite High
Helminth Infection 4 78.48 Quite High
Volume Depletion And Dehydration 4 46.48 Quite Low
Pressure And Volume Under Development 28 39.68 Quite Low
Polycystic Kidney Disease 28 34.68 Quite Low
Cyst 12 8.64 Low Low
Congenital Anomalies 8 7.00 Low Low
Hyperalgesia 4 5.00 Very Low Very Low Very Low
Renal Failure 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with its expression pattern in C. elegans and these mammalian tissues, TRPV4 localized to the cilia of polarized MDCK cells, where it colocalized with TRPP2 (Fig. 1, A–D; and Fig.
Localization (colocalized) of TRPP2 in MDCK
1) Confidence 0.74 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.16 Pain Relevance 0.15
In brief, a loxP site was inserted in intron 10 of Pkd2 and a loxP-FRT-PGKneo-FRT cassette in intron 13 (Pkd2Tm1Tjw).
Localization (inserted) of Pkd2 in FRT
2) Confidence 0.74 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.19 Pain Relevance 0
Thus, transiently expressed TRPP2 appears not to localize efficiently at the surface of HEK 293T cells.
Neg (not) Localization (localize) of TRPP2
3) Confidence 0.74 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0 Pain Relevance 0
Conversely, precipitation of the carboxy terminus of TRPV4 immobilized wild-type TRPP2 (Fig. 1 G).
Localization (immobilized) of TRPP2
4) Confidence 0.70 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0 Pain Relevance 0.08

General Comments

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