INT241245

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.35
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (PKD2) endoplasmic reticulum (PKD2) plasma membrane (PKD2)
cilium (PKD2) transmembrane transport (PKD2) cytoplasm (PKD2)
Anatomy Link Frequency
tail 1
kidney 1
PKD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
tail-flick 1 32.32 Quite Low
imagery 29 5.00 Very Low Very Low Very Low
TRP channel 9 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Mechanosensation 2 5.00 Very Low Very Low Very Low
Calcium channel 2 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autosomal Dominant Polycystic Kidney 112 97.58 Very High Very High Very High
Cv Unclassified Under Development 20 96.24 Very High Very High Very High
Left Ventricular Hypertrophy 15 94.88 High High
Calcification 1 92.56 High High
Pathologic Constriction 1 91.84 High High
Targeted Disruption 6 86.00 High High
Pericardial Effusion 2 80.92 Quite High
Double Outlet Right Ventricle 1 79.84 Quite High
Cardiovascular Disorder Under Development 1 77.16 Quite High
Chronic Renal Failure 26 73.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After removal of Pgkneo, Cre-mediated recombination (B6.129S4-Meox2tm1(cre)Sor/J; the Jackson Laboratory) between the loxP sites was predicted to result in loss of the carboxy-terminal tail of the protein (Pkd2Tm1Tjw).
Negative_regulation (loss) of Pkd2 in tail
1) Confidence 0.42 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.17 Pain Relevance 0
Therefore, the cardiovascular complications seen in ADPKD patients begin to be recognized not only as a consequence of declining kidney function, but also as a defect due to the loss of polycystin-1 and/or polycystin-2 function in cardiovascular organs [31].

2.3.

Negative_regulation (loss) of polycystin-2 in kidney associated with autosomal dominant polycystic kidney
2) Confidence 0.08 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC3017903 Disease Relevance 2.19 Pain Relevance 0

General Comments

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