INT241246

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Context Info
Confidence 0.48
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.47
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Pkd2, Trpv4) plasma membrane (Pkd2, Trpv4) cilium (Pkd2, Trpv4)
transmembrane transport (Pkd2, Trpv4) cytoskeletal protein binding (Pkd2) endoplasmic reticulum (Pkd2)
Pkd2 (Mus musculus)
Trpv4 (Mus musculus)
Pain Link Frequency Relevance Heat
TRP channel 16 67.44 Quite High
imagery 4 5.00 Very Low Very Low Very Low
Mechanosensation 4 5.00 Very Low Very Low Very Low
tail-flick 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Thermal hyperalgesia 2 5.00 Very Low Very Low Very Low
qutenza 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 14 95.44 Very High Very High Very High
Polycystic Kidney Disease 14 5.00 Very Low Very Low Very Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low
Stress 6 5.00 Very Low Very Low Very Low
Cyst 6 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low
Hyperalgesia 2 5.00 Very Low Very Low Very Low
Renal Failure 2 5.00 Very Low Very Low Very Low
Cystic Kidney Diseases 2 5.00 Very Low Very Low Very Low
Volume Depletion And Dehydration 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, coexpression of TRPV4 significantly increased TRPP2 surface expression (Fig. 2 G), whereas TRPP2 reduced both TRPV4 surface expression and TRPV4 total protein levels (Fig. 2 I).
TRPP2 Negative_regulation (reduced) of Gene_expression (expression) of TRPV4
1) Confidence 0.48 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.24 Pain Relevance 0.03
Interestingly, coexpression of TRPV4 significantly increased TRPP2 surface expression (Fig. 2 G), whereas TRPP2 reduced both TRPV4 surface expression and TRPV4 total protein levels (Fig. 2 I).
TRPP2 Negative_regulation (reduced) of Gene_expression (expression) of TRPV4
2) Confidence 0.48 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.23 Pain Relevance 0.03

General Comments

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