INT241247

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Context Info
Confidence 0.54
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 1.22
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Pkd2, Trpv4) plasma membrane (Pkd2, Trpv4) cilium (Pkd2, Trpv4)
transmembrane transport (Pkd2, Trpv4) cytoskeletal protein binding (Pkd2) endoplasmic reticulum (Pkd2)
Anatomy Link Frequency
cilium 1
ciliary 1
oocytes 1
Pkd2 (Mus musculus)
Trpv4 (Mus musculus)
Pain Link Frequency Relevance Heat
Mechanosensation 14 97.84 Very High Very High Very High
TRP channel 56 97.18 Very High Very High Very High
qutenza 7 81.92 Quite High
imagery 14 5.00 Very Low Very Low Very Low
tail-flick 7 5.00 Very Low Very Low Very Low
Inflammation 7 5.00 Very Low Very Low Very Low
Thermal hyperalgesia 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 49 87.84 High High
Polycystic Kidney Disease 49 79.28 Quite High
Stress 21 60.68 Quite High
Helminth Infection 7 59.28 Quite High
Cyst 21 53.24 Quite High
Congenital Anomalies 14 51.60 Quite High
Disease 7 48.08 Quite Low
Autosomal Dominant Polycystic Kidney 7 47.76 Quite Low
Decompression Sickness 7 24.16 Low Low
Targeted Disruption 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because TRP channels are known to engage in heteromeric interactions that generate channels with novel functional properties (Schaefer, 2005), we tested whether TRPP2 physically interacts with TRPV4.
TRPP2 Spec (whether) Binding (interacts) of TRPV4 associated with trp channel
1) Confidence 0.54 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.05 Pain Relevance 0.10
These observations led us to speculate that TRPP2 may interact with TRPV4 to mediate tissue-specific functions such as ciliary mechanosensation.
TRPP2 Binding (interact) of TRPV4 in ciliary associated with mechanosensation
2) Confidence 0.54 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.12 Pain Relevance 0.10
To confirm these coimmunoprecipitation assays, we used fluorescence resonance energy transfer (FRET) to test whether the carboxy-terminal domains of TRPP2 and TRPV4 associate within living cells.
TRPP2 Binding (associate) of TRPV4
3) Confidence 0.40 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.05 Pain Relevance 0.08
Functional interaction between TRPP2 and TRPV4
TRPP2 Binding (interaction) of TRPV4
4) Confidence 0.40 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.14 Pain Relevance 0.06
TRPV4 localizes to the cilium and interacts with TRPP2
TRPP2 Binding (interacts) of TRPV4 in cilium
5) Confidence 0.40 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.30 Pain Relevance 0.13
We also observed a functional interaction between TRPP2 and TRPV4 in HEK 293 cells (Fig.
TRPP2 Binding (interaction) of TRPV4
6) Confidence 0.40 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.37 Pain Relevance 0
To study whether TRPP2 and TRPV4 also interact functionally, we expressed both channels in Xenopus laevis oocytes for electrophysiological analysis.
TRPP2 Binding (interact) of TRPV4 in oocytes
7) Confidence 0.40 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.20 Pain Relevance 0.06

General Comments

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