INT241248

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Context Info
Confidence 0.22
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.52
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cilium (Pkd1, Pkd2) plasma membrane (Pkd1, Pkd2) transport (Pkd2)
endoplasmic reticulum (Pkd2) Golgi apparatus (Pkd1) transmembrane transport (Pkd2)
Pkd1 (Mus musculus)
Pkd2 (Mus musculus)
Pain Link Frequency Relevance Heat
TRP channel 16 97.56 Very High Very High Very High
Mechanosensation 8 5.00 Very Low Very Low Very Low
imagery 7 5.00 Very Low Very Low Very Low
Somatostatin 4 5.00 Very Low Very Low Very Low
tail-flick 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
qutenza 2 5.00 Very Low Very Low Very Low
Thermal hyperalgesia 2 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bartter Syndrome 1 92.72 High High
Decompression Sickness 2 90.84 High High
Autosomal Dominant Polycystic Kidney 3 84.48 Quite High
Cancer 1 83.84 Quite High
Disease 32 81.52 Quite High
Congenital Anomalies 10 74.96 Quite High
Apoptosis 17 74.00 Quite High
Hyperplasia 1 74.00 Quite High
Cyst 38 71.04 Quite High
Polycystic Kidney Disease 76 66.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TRPP2, a member of the transient receptor potential (TRP) family of ion channels, assembles with the PKD1 gene product polycystin-1, a large integral membrane protein with distant homology to TRP channels, to form a receptor–ion channel complex (Hanaoka et al., 2000; Köttgen, 2007).
PKD1 Binding (assembles) of TRPP2 associated with trp channel
1) Confidence 0.22 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.39 Pain Relevance 0.05
TRPP2, a member of the transient receptor potential (TRP) family of ion channels, assembles with the PKD1 gene product polycystin-1, a large integral membrane protein with distant homology to TRP channels, to form a receptor–ion channel complex (Hanaoka et al., 2000; Köttgen, 2007).
polycystin-1 Binding (assembles) of TRPP2 associated with trp channel
2) Confidence 0.22 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.40 Pain Relevance 0.05
The deregulation of Ca2+ signaling in cystic cells is believed to be mediated by polycystin-2 in complex with polycystin-1.
polycystin-1 Binding (complex) of polycystin-2
3) Confidence 0.15 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.72 Pain Relevance 0

General Comments

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