INT24128

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Context Info
Confidence 0.39
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ZAK) cell proliferation (ZAK) cell death (ZAK)
nucleus (ZAK) cell cycle (ZAK) response to stress (ZAK)
Anatomy Link Frequency
vasculature 1
ZAK (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 8 99.28 Very High Very High Very High
tetrodotoxin 1 90.48 High High
nociceptor 4 79.84 Quite High
Kinase C 1 75.00 Quite High
Pain 5 25.00 Low Low
narcan 28 5.00 Very Low Very Low Very Low
transdermal 15 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anaerobic Bacterial Infections 7 25.36 Quite Low
Myelodysplastic Syndromes 1 20.68 Low Low
Pain 4 5.00 Very Low Very Low Very Low
Wheal 3 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Diabetes Mellitus 2 5.00 Very Low Very Low Very Low
Anxiety Disorder 2 5.00 Very Low Very Low Very Low
Papular Skin Disease 1 5.00 Very Low Very Low Very Low
Overdose 1 5.00 Very Low Very Low Very Low
Chronic Renal Failure 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings indicate that increased alpha value is due to a combination of decreased PK and increased PNa.
Negative_regulation (decreased) of PK
1) Confidence 0.39 Published 1987 Journal Jpn. J. Physiol. Section Abstract Doc Link 2446032 Disease Relevance 0 Pain Relevance 0.09
In addition, staurosporine 1 microM, a PK inhibitor, suppressed both BK-induced excitation and facilitation of the heat response of testicular polymodal receptors without influencing on-going activities and the heat response itself.
Negative_regulation (inhibitor) of PK associated with bradykinin
2) Confidence 0.09 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9406872 Disease Relevance 0 Pain Relevance 0.61
Although HGPs are an appropriate model for characterization of DOP, these animals do not have sufficient surface vasculature for easy blood sampling and thus are not easily amenable to the development of a PK profile.
Negative_regulation (development) of PK in vasculature
3) Confidence 0.02 Published 2010 Journal Pharm Res Section Body Doc Link PMC3003827 Disease Relevance 0 Pain Relevance 0

General Comments

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