INT241287

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.21
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (DNMT3B) nucleus (DNMT3B) DNA binding (DNMT3B)
cytoplasm (DNMT3B)
Anatomy Link Frequency
Body 2
DNMT3B (Homo sapiens)
Pain Link Frequency Relevance Heat
backache 66 99.96 Very High Very High Very High
spinal stenosis 1 47.76 Quite Low
Sciatica 3 45.84 Quite Low
Pain 13 39.24 Quite Low
Osteoarthritis 7 5.00 Very Low Very Low Very Low
Opioid 2 5.00 Very Low Very Low Very Low
Lasting pain 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Low Back Pain 67 99.96 Very High Very High Very High
Targeted Disruption 2 99.66 Very High Very High Very High
Colon Cancer 1 97.48 Very High Very High Very High
Cancer 56 91.84 High High
Lymphatic System Cancer 15 79.96 Quite High
Carcinoma 13 79.44 Quite High
Spinal Stenosis 1 47.76 Quite Low
Nerve Root Compression 3 45.84 Quite Low
Pain 14 39.24 Quite Low
Prostate Cancer 5 38.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mean rank of the importance rating changed over time (p < 0.0001) for all four ICF components (Body Function: ?
Positive_regulation (changed) of Gene_expression (components) of ICF in Body
1) Confidence 0.40 Published 2008 Journal Health Qual Life Outcomes Section Body Doc Link PMC2614963 Disease Relevance 0 Pain Relevance 0
OPCML-v1 could also be induced in the colorectal cancer cell line HCT116 which is completely methylated for this gene, by genetic demethylation through double knock-out of both DNA methyltransferases DNMT1 and DNMT3B (DKO cell line) [25] (Fig. 4B).
Positive_regulation (methyltransferases) of Gene_expression (methyltransferases) of DNMT3B associated with targeted disruption and colon cancer
2) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 0.64 Pain Relevance 0
Linked ICF categories covered by the Comprehensive ICF Core Set for LBP
Positive_regulation (for) of Gene_expression (categories) of ICF associated with backache
3) Confidence 0.21 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770393 Disease Relevance 0.57 Pain Relevance 0.57

General Comments

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