INT24129

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Context Info
Confidence 0.70
First Reported 1987
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 13
Total Number 14
Disease Relevance 2.29
Pain Relevance 2.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ZAK) cell proliferation (ZAK) cell death (ZAK)
nucleus (ZAK) cell cycle (ZAK) response to stress (ZAK)
Anatomy Link Frequency
T-helper cell 2
testis 1
Lymphocyte 1
uterine 1
natural killer cells 1
ZAK (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 9 99.24 Very High Very High Very High
cytokine 7 98.04 Very High Very High Very High
nociceptor 4 98.04 Very High Very High Very High
Opioid 20 94.32 High High
Pain 7 93.40 High High
Dismenorea 2 93.08 High High
Dynorphin 2 91.20 High High
antagonist 4 86.88 High High
Kinase C 1 75.00 Quite High
agonist 97 69.64 Quite High
Disease Link Frequency Relevance Heat
Lymphocytosis 2 99.74 Very High Very High Very High
Cancer 15 94.16 High High
Dysmenorrhea 2 93.08 High High
Solid Tumor 5 85.56 High High
Turner's Syndrome 1 83.96 Quite High
Chronic Renal Failure 1 83.28 Quite High
Disease 8 78.08 Quite High
Virus Diseases 3 75.00 Quite High
Immunodeficiency 1 75.00 Quite High
Stress 6 66.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased MLT levels were determined and compared to MLT levels measured in a previous evaluation of the antepartum AUCs.
Positive_regulation (Increased) of MLT
1) Confidence 0.70 Published 1997 Journal J Obstet Gynaecol Section Abstract Doc Link 15511919 Disease Relevance 0 Pain Relevance 0.15
The electrogenic outward pump current seemed to protect the fibers from severe depolarization produced by the conductance abnormality (increased PNa/PK).
Positive_regulation (increased) of PK
2) Confidence 0.55 Published 1987 Journal Jpn. J. Physiol. Section Abstract Doc Link 2446032 Disease Relevance 0 Pain Relevance 0.06
The mean increase in T lymphocytes, natural killer cells, and eosinophils was significantly higher in patients treated with IL-2 plus MLT than in those who received IL-2 alone.
Positive_regulation (treated) of MLT in T lymphocytes
3) Confidence 0.44 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7825805 Disease Relevance 0.30 Pain Relevance 0.19
This preliminary study was carried out to evaluate whether the association of NTX may further enhance the lymphocytosis induced by the neuroimmunotherapy with IL-2 plus MLT.
Positive_regulation (induced) of MLT associated with lymphocytosis
4) Confidence 0.42 Published 2002 Journal Neuro Endocrinol. Lett. Section Abstract Doc Link 12195238 Disease Relevance 0.25 Pain Relevance 0.20
Elevated serum MLT levels during late-pregnancy and labour may influence the concentration of receptors of gonadal steroids in the gravid uterus at term and the psychic perception of painful uterine contractions during labour.
Positive_regulation (Elevated) of serum MLT in uterine associated with pain and dismenorea
5) Confidence 0.41 Published 1997 Journal J Obstet Gynaecol Section Abstract Doc Link 15511919 Disease Relevance 0.09 Pain Relevance 0.19
RESULTS: Lymphocyte mean number significantly increased after both IL-2 plus MLT and IL-2 plus MLT plus NTX.
Positive_regulation (increased) of MLT in Lymphocyte
6) Confidence 0.39 Published 2002 Journal Neuro Endocrinol. Lett. Section Body Doc Link 12195238 Disease Relevance 0.07 Pain Relevance 0
Activation of MLT receptors enhances the release of T-helper cell cytokines, such as gamma-interferon and interleukin-2 (IL-2), as well as activation of novel opioid cytokines which crossreact immunologically with both interleukin-4 and dynorphin B.
Positive_regulation (Activation) of MLT in T-helper cell associated with dynorphin, opioid and cytokine
7) Confidence 0.29 Published 1999 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 10721059 Disease Relevance 0.46 Pain Relevance 0.31
Activation of MLT receptors enhances the release of T-helper cell type 1 (Th1) cytokines, such as gamma-interferon and interleukin-2 (IL-2), as well as of novel opioid cytokines which crossreact immunologically with both interleukin-4 (IL-4) and dynorphin B.
Positive_regulation (Activation) of MLT in T-helper cell associated with dynorphin, opioid and cytokine
8) Confidence 0.20 Published 1999 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 10810540 Disease Relevance 0.28 Pain Relevance 0.24
The mean increase in T lymphocytes, natural killer cells, and eosinophils was significantly higher in patients treated with IL-2 plus MLT than in those who received IL-2 alone.
Positive_regulation (treated) of MLT in natural killer cells
9) Confidence 0.15 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7825805 Disease Relevance 0.30 Pain Relevance 0.19
The mean increase in T lymphocytes, natural killer cells, and eosinophils was significantly higher in patients treated with IL-2 plus MLT than in those who received IL-2 alone.
Positive_regulation (treated) of MLT in eosinophils
10) Confidence 0.15 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7825805 Disease Relevance 0.30 Pain Relevance 0.19
The involvement of protein kinase (PK) C activation in the effects of bradykinin (BK) on peripheral nociceptors, polymodal receptors, was examined using canine testis-spermatic nerve preparations in vitro.
Spec (examined) Positive_regulation (activation) of PK in testis associated with nociceptor and bradykinin
11) Confidence 0.15 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9406872 Disease Relevance 0 Pain Relevance 0.49
, undergoes prostacyclin- induced desensitization mediated through direct cAMP-protein kinase (PK) A phosphorylation of TP?
Positive_regulation (mediated) of PK
12) Confidence 0.10 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.04
, is subject to prostacyclin and PGD2-mediated desensitization in a mechanism involving direct protein kinase (PK) A phosphorylation of TP?
Positive_regulation (direct) of PK
13) Confidence 0.08 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.03
Comparative PK profiles were generated and are shown in Fig. 8.
Positive_regulation (generated) of PK
14) Confidence 0.02 Published 2010 Journal Pharm Res Section Body Doc Link PMC3003827 Disease Relevance 0.23 Pain Relevance 0.09

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