INT241305

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Context Info
Confidence 0.46
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 6.08
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PTPN11) cytoplasm (PTPN11)
Anatomy Link Frequency
plasma 2
hepatocytes 1
platelet 1
epithelial cells 1
PTPN11 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 2 71.20 Quite High
dexamethasone 1 61.36 Quite High
addiction 2 50.00 Quite Low
headache 8 5.00 Very Low Very Low Very Low
cva 7 5.00 Very Low Very Low Very Low
nud 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Influenza Virus Infection 22 99.50 Very High Very High Very High
Disease 131 97.92 Very High Very High Very High
Dengue 565 97.04 Very High Very High Very High
Infection 200 96.52 Very High Very High Very High
Stomach Cancer 18 95.60 Very High Very High Very High
Flavivirus Infection 163 91.16 High High
Adenocarcinoma 6 91.04 High High
Sprains And Strains 75 84.96 Quite High
Fever 41 79.68 Quite High
Hemolytic Uremic Syndrome 2 78.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A recent study demonstrated that soluble NS1 protein binds to endothelial cells and, following recognition by anti-NS1 antibodies, could contribute to plasma leakage during severe dengue virus infection [11].
NS1 Binding (binds) of in plasma associated with dengue and infection
1) Confidence 0.46 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2500180 Disease Relevance 0.77 Pain Relevance 0
A recent study demonstrated that soluble NS1 protein binds to endothelial cells and, following recognition by anti-NS1 antibodies, could contribute to plasma leakage during severe dengue virus infection [11].
NS1 Binding (recognition) of in plasma associated with dengue and infection
2) Confidence 0.36 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2500180 Disease Relevance 0.79 Pain Relevance 0
Soluble NS1 protein binds to the human endothelium in situ [11] and accumulates in hepatocytes [25], possibly contributing to viral propagation.
NS1 Binding (binds) of in hepatocytes
3) Confidence 0.34 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2500180 Disease Relevance 1.31 Pain Relevance 0
As a control, we used a recombinant influenza virus expressing an RNA-binding- and IFN antagonism-defective NS1 protein within which two basic amino acids were substituted to alanines (R38A/K41A).
NS1 Binding (binding) of associated with influenza virus infection
4) Confidence 0.11 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2940759 Disease Relevance 0.18 Pain Relevance 0
Interestingly, the NS1 protein of West Nile virus, another flavivirus which does not normally induce vasculopathy, has been shown to bind to complement regulatory factor H [15] and use this mechanism as an immune evasion mechanism.
NS1 Binding (bind) of
5) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.09 Pain Relevance 0
Interestingly, studies on NS1 protein from West Nile virus have shown that this protein can bind to factor H, recruiting this complement protein to the surface of infected cells, allowing NS1 bound cells to escape from complement-mediated lyses [15].
NS1 Binding (bound) of
6) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.23 Pain Relevance 0
(no. 8) SHP-1 is a splice variant of SHP-2, which binds with lesser affinity to PECAM-1 during platelet aggregation [70].
SHP-2 Binding (binds) of in platelet
7) Confidence 0.06 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958630 Disease Relevance 0.18 Pain Relevance 0.10
This was because the four amino acids, TIDD and TIDF, following EPIYA in segments C and D, respectively are reported to be important for the binding of SHP-2 [17], [24].
SHP-2 Binding (binding) of
8) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2768901 Disease Relevance 0 Pain Relevance 0
Recent studies reported that the East Asian type CagA containing segments EPIYA-D exhibits stronger binding activity for SHP-2 and a greater ability to induce morphological changes in epithelial cells than Western type CagA containing segments EPIYA-C [17], [20], [23].
SHP-2 Binding (activity) of in epithelial cells
9) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2768901 Disease Relevance 0.54 Pain Relevance 0

General Comments

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