INT241307

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Context Info
Confidence 0.12
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.64
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (HIF1A, EPO) cell differentiation (HIF1A) aging (EPO)
cytoplasm (HIF1A) signal transducer activity (HIF1A) extracellular space (EPO)
HIF1A (Homo sapiens)
EPO (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 93 99.98 Very High Very High Very High
Targeted Disruption 1 83.76 Quite High
Fatigue 4 5.00 Very Low Very Low Very Low
Stroke 3 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 2 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 2 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 1 5.00 Very Low Very Low Very Low
Pressure Volume 2 Under Development 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, prolonged rhEpo treatment stimulates erythropoiesis without increasing hypoxia-inducible factor (HIF-1) levels, while during prolonged hypoxia HIF-1 accumulation triggers Epo gene activation therefore promoting erythropoiesis but also targets many other genes involved in various physiological responses, which may also have a negative effect on V?
Positive_regulation (accumulation) of HIF-1 Positive_regulation (triggers) of Positive_regulation (activation) of Epo associated with hypoxia
1) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500186 Disease Relevance 0.64 Pain Relevance 0

General Comments

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