INT241307

Context Info Confidence 0.12 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.64 Pain Relevance 0

signal transduction (HIF1A, EPO) cell differentiation (HIF1A) aging (EPO) cytoplasm (HIF1A) signal transducer activity (HIF1A) extracellular space (EPO)

HIF1A (Homo sapiens) EPO (Homo sapiens)

Pain Link Frequency Relevance Heat anesthesia 2 5.00 Central nervous system 1 5.00

Disease Link Frequency Relevance Heat Hypoxia 93 99.98 Targeted Disruption 1 83.76 Fatigue 4 5.00 Stroke 3 5.00 Increased Venous Pressure Under Development 2 5.00 Peripheral Arterial Disease 2 5.00 Pressure And Volume Under Development 1 5.00 Pressure Volume 2 Under Development 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Indeed, prolonged rhEpo treatment stimulates erythropoiesis without increasing hypoxia-inducible factor (HIF-1) levels, while during prolonged hypoxia HIF-1 accumulation triggers Epo gene activation therefore promoting erythropoiesis but also targets many other genes involved in various physiological responses, which may also have a negative effect on V?

Positive_regulation (accumulation) of HIF-1 Positive_regulation (triggers) of Positive_regulation (activation) of Epo associated with hypoxia

1) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500186 Disease Relevance 0.64 Pain Relevance 0

General Comments

This test has worked.