INT241407

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Context Info
Confidence 0.24
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.16
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (C3) extracellular space (C3) extracellular region (C3)
Anatomy Link Frequency
nucleus 1
neurite 1
NFAT 1
C3 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 1 100.00 Very High Very High Very High
unmyelinated 4 81.56 Quite High
Spinal cord 19 81.40 Quite High
nav1.8 2 66.28 Quite High
c fibre 2 65.72 Quite High
Central nervous system 31 54.88 Quite High
Peripheral nervous system 7 50.96 Quite High
Demyelination 12 48.28 Quite Low
dorsal root ganglion 7 5.00 Very Low Very Low Very Low
cINOD 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Spinal Cord Injury 16 81.68 Quite High
Demyelinating Disease 14 48.28 Quite Low
Targeted Disruption 9 42.84 Quite Low
Injury 8 21.96 Low Low
Disease 18 5.00 Very Low Very Low Very Low
Stroke 15 5.00 Very Low Very Low Very Low
Ganglion Cysts 7 5.00 Very Low Very Low Very Low
Adhesions 4 5.00 Very Low Very Low Very Low
Neuropathic Pain 4 5.00 Very Low Very Low Very Low
Cv General 3 Under Development 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This activates the phosphatase calcineurin, which dephosphorylates nuclear factor of activated T cells (NFAT) c3 and c4, resulting in translocation to the nucleus.
Phosphorylation (dephosphorylates) of c3 in nucleus
1) Confidence 0.24 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948355 Disease Relevance 0 Pain Relevance 0.26
Lack of calcineurin B prevents neuregulin-induced dephosphorylation and activation of NFAT c3 and c4.
Phosphorylation (dephosphorylation) of c3 in NFAT
2) Confidence 0.21 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948355 Disease Relevance 0 Pain Relevance 0.03
Botulinum toxin C3, which specifically inactivates Rho by enzymatic adenosine diphosphate (ADP)-ribosylation of the active site in Rho blocks neurite outgrowth inhibition by myelin and MAG (Lehmann et al 1999).
Phosphorylation (ribosylation) of C3 in neurite associated with adenocard
3) Confidence 0.20 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2500253 Disease Relevance 0.16 Pain Relevance 0.13

General Comments

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