INT24141

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Context Info
Confidence 0.59
First Reported 1980
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 24
Total Number 26
Disease Relevance 16.82
Pain Relevance 8.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Apcs) extracellular region (Apcs) protein complex assembly (Apcs)
protein complex (Apcs)
Anatomy Link Frequency
tube 1
nerves 1
spleen 1
thymus 1
head 1
Apcs (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 84 100.00 Very High Very High Very High
agonist 49 100.00 Very High Very High Very High
Action potential 10 100.00 Very High Very High Very High
Dorsal horn 4 100.00 Very High Very High Very High
intrathecal 16 99.98 Very High Very High Very High
lidocaine 6 99.88 Very High Very High Very High
substance P 14 99.80 Very High Very High Very High
opioid receptor 2 99.40 Very High Very High Very High
c fibre 2 99.36 Very High Very High Very High
Inflammation 43 99.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pancreatitis 182 100.00 Very High Very High Very High
Heart Rate Under Development 28 99.96 Very High Very High Very High
Hypertension 60 99.84 Very High Very High Very High
Obstructive Jaundice 96 99.80 Very High Very High Very High
INFLAMMATION 71 99.48 Very High Very High Very High
Death 106 99.40 Very High Very High Very High
Anxiety Disorder 15 99.36 Very High Very High Very High
Pressure Volume 2 Under Development 21 99.02 Very High Very High Very High
Apoptosis 168 99.00 Very High Very High Very High
Body Weight 6 97.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ouabain (2 mg/kg), given by i.p. injection to unanesthetized rats, produced a significant decrease in SAP in both SH and NT rats with little concomitant HR change.
Negative_regulation (decrease) of SAP associated with hypertension
1) Confidence 0.59 Published 1980 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7205616 Disease Relevance 0.71 Pain Relevance 0.08
Reductions of SAP and intentions with concomitant reductions of crossings (nonspecific antiambivalent effects) were established for the alpha 2-adrenoceptor agonist clonidine and the MAO inhibitor clorgyline.
Negative_regulation (Reductions) of SAP associated with agonist and clonidine
2) Confidence 0.55 Published 1995 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 8539344 Disease Relevance 0.07 Pain Relevance 0.32
The putative anxiogenic drug pentylenetetrazol false positively reduced SAP while increasing exploration.
Negative_regulation (reduced) of SAP
3) Confidence 0.55 Published 1995 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 8539344 Disease Relevance 0.13 Pain Relevance 0.58
The 5-HT uptake inhibitor fluvoxamine suppressed intention movements, but not SAP.
Negative_regulation (suppressed) of SAP
4) Confidence 0.55 Published 1995 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 8539344 Disease Relevance 0.07 Pain Relevance 0.35
In conclusion, SAP and intention movements were reduced selectively by anxiolytic agents from different classes, including benzodiazepine receptor agonists, 5-HT1A receptor agonists and a 5-HT uptake inhibitor, whereas an alpha 2-adrenoceptor agonist and a MAO inhibitor reduced SAP non-selectively.
Negative_regulation (reduced) of SAP associated with anxiety disorder and agonist
5) Confidence 0.55 Published 1995 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 8539344 Disease Relevance 0.17 Pain Relevance 0.58
The benzodiazepine receptor agonists chlordiazepoxide, diazepam and alprazolam, the 5-HT1A receptor agonists flesinoxan and ipsapirone and the 5-HT uptake inhibitor clomipramine selectively (no effect on crossings) reduced SAP.
Negative_regulation (reduced) of SAP associated with agonist
6) Confidence 0.55 Published 1995 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 8539344 Disease Relevance 0.07 Pain Relevance 0.26
Ouabain was administered i.p. 30 min after induction of anesthesia with alpha-chloralose (60 mg/kg i.p.). alpha-Chloralose alone produced a significant SAP decrease in both SH and NT rats and bradycardia in SH but no significant HR change in NT rats.
Negative_regulation (decrease) of SAP associated with heart rate under development, anesthesia and hypertension
7) Confidence 0.43 Published 1980 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7205616 Disease Relevance 1.03 Pain Relevance 0.10
Digitoxin, given by stomach tube (4--5 mg/kg) for 1 week, decreased SAP in SH but not NT rats.
Negative_regulation (decreased) of SAP in tube associated with hypertension
8) Confidence 0.43 Published 1980 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7205616 Disease Relevance 1.20 Pain Relevance 0.08
Ouabain i.p. further reduced SAP in SH but had no effect on NT rats.
Negative_regulation (reduced) of SAP associated with hypertension
9) Confidence 0.43 Published 1980 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7205616 Disease Relevance 1.11 Pain Relevance 0.09
The specificity of this temporal relationship between LF power, loss of SAP, asystole and death was confirmed when microinjection bilaterally of the same dose of Mev (280 nmol) into sites adjacent to the RVLM failed to elicit these events (Fig. 3).


Negative_regulation (loss) of SAP associated with heart rate under development, rostral ventrolateral medulla and death
10) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2766834 Disease Relevance 1.03 Pain Relevance 0.38
When given by i.a. bolus injection (250 microgram in 0.1 mg of heparin-saline) to anesthetized (pentobarbital, 40 mg/kg i.p.) rats with intact left carotid sinus nerves, ouabain produced a transient but significant reduction in SAP of SH but NT rats or SH rats with sinoaortic denervation.
Negative_regulation (reduction) of SAP in nerves associated with hypertension
11) Confidence 0.37 Published 1980 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7205616 Disease Relevance 1.21 Pain Relevance 0.08
Substance P had no effect but spantide suppressed the APcs of both A- and C-fibers in a dose-dependent manner and this suppression was reversible at 10(-4) M but irreversible at 10(-3) M.
Negative_regulation (suppressed) of APcs associated with c fibre, action potential and substance p
12) Confidence 0.37 Published 1987 Journal Neuropeptides Section Abstract Doc Link 2446192 Disease Relevance 0 Pain Relevance 0.90
Lidocaine also suppressed the APcs reversibly but spantide was more potent than lidocaine.
Negative_regulation (suppressed) of APcs associated with action potential and lidocaine
13) Confidence 0.37 Published 1987 Journal Neuropeptides Section Abstract Doc Link 2446192 Disease Relevance 0 Pain Relevance 0.90
A head-down tilt maneuver in mice substantially attenuated the antigen-induced decrease in Sap throughout the 60 min measurements, though it aggravated slightly, but significantly, only at the late phase of after 25 min in rats.
Negative_regulation (decrease) of Sap in head
14) Confidence 0.36 Published 2007 Journal J Physiol Sci Section Abstract Doc Link 17875232 Disease Relevance 0.77 Pain Relevance 0
Specifically, our results showed that whether animals subsequently manifested asystole, loss of SAP and died (Figs. 1a and 2) or exhibited resumption of spontaneous circulation (Figs. 1b and 2) depended on whether the augmented LF power persisted beyond this critical time-window.
Spec (whether) Negative_regulation (loss) of SAP associated with heart rate under development
15) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2766834 Disease Relevance 0.64 Pain Relevance 0.16
In contrast, in control mice injected with antigen, Sap decreased similarly, but Pvp increased by only 4 cmH(2)O.
Negative_regulation (decreased) of Sap
16) Confidence 0.26 Published 2007 Journal J Physiol Sci Section Abstract Doc Link 17875232 Disease Relevance 0.77 Pain Relevance 0
After treatment with Salvia miltiorrhizae injection, the expression of Bax protein in the spleen and thymus was, to varying degrees, downregulated, the apoptosis index decreased, and the pathological damage was improved in SAP and OJ rats.
Negative_regulation (improved) of SAP in thymus associated with pancreatitis, apoptosis and obstructive jaundice
17) Confidence 0.25 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2790077 Disease Relevance 1.27 Pain Relevance 0
successful preparation of SAP model.
Negative_regulation (preparation) of SAP associated with pancreatitis
18) Confidence 0.21 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234334 Disease Relevance 0.28 Pain Relevance 0.14
In AP/SAP, glucocorticoid
(represented by dexamethasone) mainly inhibits the generation and/or effect of
Negative_regulation (inhibits) of SAP associated with pancreatitis and dexamethasone
19) Confidence 0.21 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234334 Disease Relevance 2.69 Pain Relevance 0.36
LPS also induced an immediate hypotension, followed by a rebound increase and a secondary decrease in SAP.
Negative_regulation (decrease) of SAP associated with pressure volume 2 under development
20) Confidence 0.19 Published 2001 Journal Shock Section Abstract Doc Link 11198360 Disease Relevance 0.56 Pain Relevance 0.28

General Comments

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