INT241456

Context Info Confidence 0.01 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

Golgi apparatus (Rock1) cytoskeleton (Rock1) cytoskeleton organization (Rock1) kinase activity (Rock1) cellular_component (Tgtp1) cytoplasm (Rock1)

Tgtp1 (Mus musculus) Rock1 (Mus musculus)

Pain Link Frequency Relevance Heat Central nervous system 29 15.92 Spinal cord 19 5.00 cINOD 6 5.00 Kinase C 5 5.00 cva 5 5.00 Peripheral nervous system 3 5.00 ischemia 3 5.00 dorsal root ganglion 1 5.00 adenocard 1 5.00 Intracerebroventricular 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 2 38.96 Disease 18 5.00 Spinal Cord Injury 16 5.00 Stroke 15 5.00 Targeted Disruption 7 5.00 Injury 6 5.00 Cv General 3 Under Development 3 5.00 Optic Nerve Injuries 3 5.00 Cv Unclassified Under Development 3 5.00 Alzheimer's Dementia 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It has been suggested that the GTP-bound form of Rho activates ROCK by binding to the RBD in ROCK and counteracting the inhibitory interaction between the catalytic domain and the autoinhibitory region (Figure 1B).

GTP Positive_regulation (activates) of ROCK

1) Confidence 0.01 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2500253 Disease Relevance 0 Pain Relevance 0

General Comments

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