INT241468

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Context Info
Confidence 0.13
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.41
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Dhfr) mRNA binding (Dhfr)
Anatomy Link Frequency
blood 1
Dhfr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
methotrexate 7 99.20 Very High Very High Very High
Inflammation 12 56.80 Quite High
fibrosis 2 22.96 Low Low
corticosteroid 4 5.00 Very Low Very Low Very Low
Paracetamol 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Infliximab 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diarrhoea 2 89.52 High High
Vomiting 7 88.96 High High
Syndrome 2 86.92 High High
Hypersensitivity 2 86.56 High High
Malignant Neoplastic Disease 2 85.20 High High
Infection 10 84.72 Quite High
Pancytopenia 2 84.28 Quite High
Leukopenia 2 83.72 Quite High
Adverse Drug Reaction 1 78.84 Quite High
Pemphigoid 49 71.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, the high prevalence of pfcrt, pfmdr1, dhfr and dhps mutations and their association with high failure rates in-vivo to SP, AQ and the combination SPAQ supports the recommendation by the government of Cameroon in changing its first-line treatment away from monotherapies in favour of artemisinin-based combination therapy and established the baseline for mutations to be monitored over time.


dhfr Binding (association) of
1) Confidence 0.13 Published 2010 Journal Malar J Section Body Doc Link PMC2831903 Disease Relevance 0.06 Pain Relevance 0
The prevalence of mutations associated with resistance in the pfcrt, pfmdr, dhfr and dhps genes in initial blood samples obtained at Mutengene, Yaoundé and Garoua respectively are shown in Figure 3.
dhfr Binding (associated) of in blood
2) Confidence 0.12 Published 2010 Journal Malar J Section Body Doc Link PMC2831903 Disease Relevance 0.11 Pain Relevance 0
Methotrexate is an antimetabolite that irreversibly binds to dihydrofolate reductase.
dihydrofolate reductase Binding (binds) of associated with methotrexate
3) Confidence 0.01 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2500254 Disease Relevance 1.24 Pain Relevance 0.17

General Comments

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