INT2415

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.47
First Reported 1979
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 26
Total Number 27
Disease Relevance 13.26
Pain Relevance 11.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MAOA) small molecule metabolic process (MAOA) oxidoreductase activity (MAOA)
Anatomy Link Frequency
brain 1
platelets 1
cortex 1
MAOA (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 201 100.00 Very High Very High Very High
monoamine 107 100.00 Very High Very High Very High
tricyclic antidepressant 44 100.00 Very High Very High Very High
Catechol-O-methyltransferase 22 100.00 Very High Very High Very High
gABA 16 100.00 Very High Very High Very High
tolerance 9 100.00 Very High Very High Very High
Endocannabinoid 5 100.00 Very High Very High Very High
opiate 1 100.00 Very High Very High Very High
Dopamine 230 99.96 Very High Very High Very High
Migraine 23 99.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 204 100.00 Very High Very High Very High
Anxiety Disorder 472 99.80 Very High Very High Very High
Targeted Disruption 5 99.76 Very High Very High Very High
Epilepsy 4 99.66 Very High Very High Very High
Migraine Without Aura 8 99.20 Very High Very High Very High
Aggression 7 99.16 Very High Very High Very High
Nicotine Addiction 695 98.64 Very High Very High Very High
Headache 26 98.04 Very High Very High Very High
Reprotox - General 2 62 96.96 Very High Very High Very High
Depression 264 96.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this updated theory, long-term monoamine loss because of this global MAO-A activity interacts with regional specific transporter densities (i.e. 5-HT, NE), resulting in the expression of the depressive illness (58).
MAO-A Binding (interacts) of associated with depression and monoamine
1) Confidence 0.47 Published 2007 Journal International Journal of Clinical Practice Section Body Doc Link PMC2228409 Disease Relevance 0.99 Pain Relevance 0.70
We have investigated the possible association of MAO-A and -B alleles and haplotypes with two common types of migraine, i.e. migraine without aura (MO) and migraine with aura (MA), on the sample of 110 migraineours (80 MO and 30 MA) and 150 controls.
MAO-A Binding (association) of associated with migraine with aura, migraine and migraine without aura
2) Confidence 0.47 Published 2005 Journal J. Neurol. Sci. Section Abstract Doc Link 15694196 Disease Relevance 0.99 Pain Relevance 0.83
Patients, however, were instructed to check with the study investigator prior to initiating medications that have been historically known to interact with monoamine oxidase inhibitors (eg, over-the-counter cold preparations, narcotic and non-narcotic analgesics, antidepressants, antihypertensives).
monoamine oxidase Binding (interact) of associated with antidepressant, analgesic and monoamine
3) Confidence 0.38 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656289 Disease Relevance 0.17 Pain Relevance 0.27
We have found a tendency toward association of the shorter variant of MAO-A gene promoter with migraine without aura in male subjects.
MAO-A Binding (association) of associated with migraine
4) Confidence 0.36 Published 2005 Journal J. Neurol. Sci. Section Abstract Doc Link 15694196 Disease Relevance 1.07 Pain Relevance 0.99
This paper outlines changes in prescribing, the problems associated with monoamineoxidase (MAO) inhibitors and how they relate to the practice of anaesthesia.
monoamineoxidase Binding (associated) of
5) Confidence 0.36 Published 1979 Journal Anaesth Intensive Care Section Abstract Doc Link 434448 Disease Relevance 0.10 Pain Relevance 0.05
It interacts with NE transporters at 0.1 microM, DA transporters at about 1 microM, 5-HT transporters at 15 microM and MAO-A at about 100 microM.
MAO-A Binding (interacts) of
6) Confidence 0.36 Published 1999 Journal Synapse Section Abstract Doc Link 10231134 Disease Relevance 0.10 Pain Relevance 0.04
With the advent of reversible, specific inhibitors of MAO-A (RIMAs) there is less potential for dietary and drug interaction.
MAO-A Binding (interaction) of
7) Confidence 0.36 Published 1992 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 1546140 Disease Relevance 0 Pain Relevance 0.12
Significant associations between cold pain tolerance and DAT-1 (p=0.008) and MAO-A (p=0.024) polymorphisms were found.
MAO-A Binding (associations) of associated with pain and tolerance
8) Confidence 0.36 Published 2009 Journal Pain Section Abstract Doc Link 19796878 Disease Relevance 0.81 Pain Relevance 1.25
These tricyclic-MAO interactional data suggest that secondary and tertiary amine tricyclics interact differently with human MAO type B, that rat and human MAO type B are not functionally identical, and also support other data that phenylethylamine and benzylamine are deaminated by different mechanisms.
MAO Binding (interact) of
9) Confidence 0.35 Published 1988 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 3244400 Disease Relevance 0 Pain Relevance 0.33
An important but complex MAO-A interaction between a metabolite of propranolol and rizatriptan mandates dosage reduction (to 5 mg) for rizatriptan in the presence of propranolol treatment.
MAO-A Binding (interaction) of
10) Confidence 0.35 Published 2000 Journal Expert Opin Pharmacother Section Abstract Doc Link 11249525 Disease Relevance 0.13 Pain Relevance 0.76
While compulsive/aggressive behavior was observed in MAOA knockout mice [35], MAO activity has not been investigated for its possible association with pain phenotypes.
MAO Binding (association) of associated with targeted disruption, pain and aggression
11) Confidence 0.35 Published 2006 Journal Mol Pain Section Body Doc Link PMC1543620 Disease Relevance 0.44 Pain Relevance 0.31
Interactions of tricyclic antidepressant drugs with human and rat monoamine oxidase type B.
monoamine oxidase Binding (Interactions) of associated with tricyclic antidepressant and monoamine
12) Confidence 0.32 Published 1988 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 3244400 Disease Relevance 0 Pain Relevance 0.38
Recently we demonstrated a potentiation of 3H-BFI binding in human but not in rat brain by the nonselective MAO inhibitor tranylcypromine.
MAO Binding (binding) of in brain
13) Confidence 0.32 Published 1999 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10494892 Disease Relevance 0 Pain Relevance 0.05
No significant association between clinical pain and MAOA genetic variations was found in male patients.
MAOA Neg (No) Binding (association) of associated with pain
14) Confidence 0.29 Published 2006 Journal Mol Pain Section Body Doc Link PMC1543620 Disease Relevance 0.37 Pain Relevance 0.50
No cross-reaction was found with anti-monoamine oxidase (MAO) A/B antibodies and the 43-kD protein, ruling out the possibility of this protein being an MAO-associated I2R.
anti-monoamine oxidase Binding (found) of associated with monoamine
15) Confidence 0.26 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10415908 Disease Relevance 0 Pain Relevance 0.45
Selective and RIMAs exemplified by moclobemide and brofaromine, do not require dietary restrictions, have fewer drug interactions than irreversible MAO inhibitors, and are better tolerated.
MAO Binding (interactions) of
16) Confidence 0.24 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2536545 Disease Relevance 1.15 Pain Relevance 0.41
Somatostatin releasing inhibitory factor, vasopressin, and oxytocin were detected in the hypothalamus from weeks 12 to 14 onwards, and monoamine oxidase, succinic dehydrogenase, parvalbumin, calbindin D28K, and vasoactive intestinal peptide were found in the visual cortex at midgestation.
monoamine oxidase Binding (found) of in cortex associated with somatostatin and monoamine
17) Confidence 0.23 Published 1999 Journal Microsc. Res. Tech. Section Abstract Doc Link 10402266 Disease Relevance 0 Pain Relevance 0.71
Phenelzine, isocarboxazid and tranylcypromine are irreversible nonselective inhibitors, and their effect may persist for weeks until the regeneration of MAO.
MAO Binding (regeneration) of
18) Confidence 0.18 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938284 Disease Relevance 0.54 Pain Relevance 0.50
Several PET receptor ligands have been used to investigate the neurochemical basis of the epilepsies. 11C-Flumazenil binds to the central benzodiazepine receptor (cBZR)-gamma-aminobutyric acid (GABA) A receptor complex; 11C-diprenorphine, 18F-cyclofoxy, and 11C-carfentanil to opiate receptors; and 11C-Deprenyl to monoamine oxidase B.
monoamine oxidase Binding (binds) of associated with epilepsy, gaba, opiate and monoamine
19) Confidence 0.17 Published 1999 Journal Adv Neurol Section Abstract Doc Link 10514872 Disease Relevance 0.24 Pain Relevance 0.37
Future studies may also like to consider functional polymorphisms in MAO-B and catechol-O-methyltransferase (COMT), which also metabolize dopamine [33].


MAO Binding (metabolize) of associated with catechol-o-methyltransferase and dopamine
20) Confidence 0.15 Published 2004 Journal Tob Induc Dis Section Body Doc Link PMC2669467 Disease Relevance 0.67 Pain Relevance 0.36

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox