INT241509

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Context Info
Confidence 0.20
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.02
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lyn) Golgi apparatus (Lyn) plasma membrane (Lyn)
nucleus (Lyn) enzyme binding (Lyn) kinase activity (Lyn)
Anatomy Link Frequency
eosinophil 2
Lyn (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 1 95.28 Very High Very High Very High
cytokine 24 22.52 Low Low
Bioavailability 3 21.84 Low Low
Inflammation 18 5.00 Very Low Very Low Very Low
corticosteroid 6 5.00 Very Low Very Low Very Low
Paracetamol 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
lidocaine 3 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 24 98.90 Very High Very High Very High
Leukemia 14 85.60 High High
Disease 38 78.68 Quite High
Apoptosis 79 75.32 Quite High
Myeloid Leukemia 86 69.36 Quite High
Chronic Myeloid Leukemia 2 55.60 Quite High
Cancer 12 49.48 Quite Low
Blast Crisis 19 23.40 Low Low
Asthma 24 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 23 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The role of Src kinases for imatinib resistance has been further supported by the finding that siRNA-mediated inhibition of Lyn expression significantly reduced proliferation and survival of imatinib resistant Bcr-Abl positive cells (Ptasznik et al 2004).
Negative_regulation (inhibition) of Gene_expression (expression) of Lyn
1) Confidence 0.20 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503652 Disease Relevance 0.41 Pain Relevance 0
Ligation of Fas by agonistic antibody has been shown to result in tyrosine phosphorylation of several intracellular proteins and tyrosine kinase inhibitors lavendustin A and genistein have been reported to block Fas-receptor-induced cell death.109 Lyn phosphorylation by Fas has been reported, and decreases in the expression of Lyn by antisense technique resulted in partial reversal of Fas-induced cell death.109 Similarly, nitric oxide and cyclic adenosine 3':5'-monophosphate (cAMP) and cGMP have been reported to reverse Fas-induced eosinophil death.128 Fas-ligation induces caspase-3 and -8 activation and loss of mitochondrial membrane potential (??
Negative_regulation (decreases) of Gene_expression (expression) of Lyn in eosinophil associated with adenocard and death
2) Confidence 0.12 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846745 Disease Relevance 0.61 Pain Relevance 0.05

General Comments

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