INT241535

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.53
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Abl1, Jak2) cytosol (Abl1, Jak2) nucleus (Abl1, Jak2)
cytoskeleton (Abl1, Jak2) kinase activity (Abl1, Jak2) cell differentiation (Jak2)
Abl1 (Mus musculus)
Jak2 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 4 5.00 Very Low Very Low Very Low
Bioavailability 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
fluoxetine 1 5.00 Very Low Very Low Very Low
anticonvulsant 1 5.00 Very Low Very Low Very Low
beta blocker 1 5.00 Very Low Very Low Very Low
carbamazepine 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leukemia 14 96.92 Very High Very High Very High
Cancer 9 90.44 High High
Myeloid Leukemia 86 83.60 Quite High
Apoptosis 2 72.16 Quite High
Toxicity 13 56.08 Quite High
Pressure And Volume Under Development 23 5.00 Very Low Very Low Very Low
Blast Crisis 19 5.00 Very Low Very Low Very Low
Disease 18 5.00 Very Low Very Low Very Low
Heart Rate Under Development 9 5.00 Very Low Very Low Very Low
Hepatotoxicity 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One major effect of the JAK2 activation by Bcr-Abl is the increase in c-Myc expression (Xie et al 2002) which is important for leukemia induction (Sawyers et al 1992).
Abl Regulation (effect) of Positive_regulation (activation) of JAK2 associated with leukemia
1) Confidence 0.10 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503652 Disease Relevance 0.53 Pain Relevance 0

General Comments

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