INT241536

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.17
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcb1b, Abcg2) ATPase activity (Abcb1b, Abcg2) mitochondrion (Abcb1b)
plasma membrane (Abcg2) nucleus (Abcg2) transmembrane transport (Abcb1b)
Abcb1b (Mus musculus)
Abcg2 (Mus musculus)
Pain Link Frequency Relevance Heat
Bioavailability 3 74.56 Quite High
Paracetamol 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
fluoxetine 1 5.00 Very Low Very Low Very Low
anticonvulsant 1 5.00 Very Low Very Low Very Low
beta blocker 1 5.00 Very Low Very Low Very Low
carbamazepine 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 1 100.00 Very High Very High Very High
Myeloid Leukemia 86 66.24 Quite High
Leukemia 14 50.00 Quite Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 40.40 Quite Low
Pressure And Volume Under Development 23 5.00 Very Low Very Low Very Low
Blast Crisis 19 5.00 Very Low Very Low Very Low
Disease 18 5.00 Very Low Very Low Very Low
Toxicity 13 5.00 Very Low Very Low Very Low
Heart Rate Under Development 9 5.00 Very Low Very Low Very Low
Cancer 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Imatinib clearance is most strongly associated with the multi drug resistance transporter P-glycoprotein the gene product of the multi drug resistance gene 1 (MDR1), also termed as ABCB1 (Illmer et al 2004) and by the breast cancer resistance protein BCRP (ABCG2; Ozvegy-Laczka et al 2004; Burger et al 2004).
ABCB1 Binding (termed) of BCRP associated with breast cancer
1) Confidence 0.10 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503652 Disease Relevance 0.17 Pain Relevance 0.04

General Comments

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