INT241581

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.44
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.34
Pain Relevance 2.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Htr4) plasma membrane (Htr4) cytoplasm (Htr4)
signal transducer activity (Htr4)
Anatomy Link Frequency
pyramidal neurons 1
neuron 1
5-HT neurons 1
afferent neurons 1
Htr4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
5HT 5 99.98 Very High Very High Very High
agonist 220 99.96 Very High Very High Very High
sSRI 188 99.64 Very High Very High Very High
Calcitonin gene-related peptide 9 99.50 Very High Very High Very High
Neurotransmitter 6 97.20 Very High Very High Very High
Hippocampus 32 95.48 Very High Very High Very High
Pyramidal cell 68 94.88 High High
abdominal pain 14 94.64 High High
antagonist 23 92.96 High High
Visceral pain 10 82.40 Quite High
Disease Link Frequency Relevance Heat
Constipation 34 99.96 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

138 99.40 Very High Very High Very High
Abdominal Pain 14 94.64 High High
Intestinal Pseudo-obstruction 1 86.60 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

10 82.40 Quite High
Diarrhoea 34 77.88 Quite High
Dyspepsia 14 52.56 Quite High
Vomiting 3 52.16 Quite High
Stress 5 46.48 Quite Low
Volume Depletion And Dehydration 1 41.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The 5HT4 agonist tegaserod potentiates peristalsis initiated by 5HT1 receptor stimulation by acting on pre-synaptic 5HT4 receptors and augmenting the release of neurotransmitters (Grider 1996; Gershon 2004, 2005). 5HT4 agonists are therefore useful in constipation predominant form of IBS and in chronic constipation. 5HT4 receptors are not present on extrinsic afferent neurons and therefore do not directly modulate sensation.
Neg (not) Regulation (modulate) of 5HT4 in afferent neurons associated with neurotransmitter, constipation and agonist
1) Confidence 0.44 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503665 Disease Relevance 0.71 Pain Relevance 0.67
It also indirectly suggests that the effect of 5-HT4 agonists on pCREB formation might not result from a dual action, namely a direct stimulation of the 5-HT4 receptors located on pyramidal neurons in addition to a global facilitation of 5-HT function, as previously proposed [37].
Regulation (effect) of 5-HT4 in pyramidal neurons associated with pyramidal cell and agonist
2) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821932 Disease Relevance 0 Pain Relevance 0.25
Again, this hypothesis remains to be experimentally confirmed, and lesion/depletion studies are currently underway in our laboratory to determine the extent to which hippocampal 5-HT4 receptors are involved in the facilitatory effect of 5-HT4 agonists on CREB activation.
Regulation (effect) of 5-HT4 associated with agonist
3) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821932 Disease Relevance 0 Pain Relevance 0.40
These investigators proposed that the primary intrinsic afferent involved in this reflex is a CGRP neuron activated by 5HT acting on 5HT4 receptors [25].
Regulation (acting) of 5HT4 in neuron associated with 5ht and calcitonin gene-related peptide
4) Confidence 0.26 Published 2010 Journal Gut Pathog Section Body Doc Link PMC2876056 Disease Relevance 0.06 Pain Relevance 0.37
That the effect of prucalopride remains so remarkably stable in the presence of two different, structurally unrelated compounds with differential potencies as 5-HT reuptake blockers [28] further supports the idea that the 5-HT4-mediated control on 5-HT neurons is independent from SSRI-triggered mechanism(s) of action.
Regulation (control) of 5-HT4-mediated in 5-HT neurons associated with ssri
5) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821932 Disease Relevance 0 Pain Relevance 0.28
More importantly, they also strongly suggest that the mechanisms underlying, respectively the 5-HT4-dependent excitatory control and the SSRI-induced decrease of 5-HT function, are fully independent from each other.
Regulation (control) of 5-HT4-dependent associated with ssri
6) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821932 Disease Relevance 0 Pain Relevance 0.22

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox