INT241608

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Context Info
Confidence 0.67
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.20
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
ACC neurons 1
Acc (Mus musculus)
Pain Link Frequency Relevance Heat
Anterior cingulate cortex 37 100.00 Very High Very High Very High
allodynia 10 96.42 Very High Very High Very High
Lasting pain 17 95.92 Very High Very High Very High
Neuronal excitability 2 85.92 High High
Pain 9 70.80 Quite High
Inflammation 2 58.72 Quite High
alcohol 12 50.00 Quite Low
tolerance 6 43.04 Quite Low
Pyramidal cell 1 10.00 Low Low
long-term potentiation 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 11 96.42 Very High Very High Very High
Pain 29 95.92 Very High Very High Very High
Amputation 19 59.32 Quite High
INFLAMMATION 2 58.72 Quite High
Injury 11 54.16 Quite High
Coronary Heart Disease 4 50.00 Quite Low
Nervous System Injury 5 45.24 Quite Low
Impaired Glucose Tolerance 10 43.04 Quite Low
Toxicity 7 5.00 Very Low Very Low Very Low
Targeted Disruption 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We went on to examine the involvement of LKB1 in ADH and ethanol-induced response in AMPK/ACC activation.
Positive_regulation (activation) of ACC
1) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0 Pain Relevance 0
In the expression phase of chronic pain (or mechanical allodynia here), in part due to prolonged plastic changes triggered in the induction phase, a normally non-noxious stimulus (i.e., non-noxious brushing of the skin) triggers a wide spread activation of Erk in ACC neurons.
Positive_regulation (activation) of ACC in ACC neurons associated with allodynia, lasting pain and anterior cingulate cortex
2) Confidence 0.49 Published 2008 Journal Mol Pain Section Body Doc Link PMC2503974 Disease Relevance 1.20 Pain Relevance 1.16

General Comments

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