INT241618

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.41
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Atf4) cytoskeleton (Atf4) nucleus (Atf4)
DNA binding (Atf4) microtubule organizing center (Atf4) cytoplasm (Atf4)
Anatomy Link Frequency
spinal cord 1
brain 1
Atf4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cocaine 584 99.76 Very High Very High Very High
ischemia 2 98.96 Very High Very High Very High
Spinal cord 62 97.88 Very High Very High Very High
Central nervous system 26 5.00 Very Low Very Low Very Low
Neurotransmitter 14 5.00 Very Low Very Low Very Low
monoamine 6 5.00 Very Low Very Low Very Low
Dopamine 6 5.00 Very Low Very Low Very Low
GABAergic 6 5.00 Very Low Very Low Very Low
cerebral cortex 4 5.00 Very Low Very Low Very Low
Neurobehavioral 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 54 99.62 Very High Very High Very High
Injury 134 99.44 Very High Very High Very High
Cv Unclassified Under Development 2 98.96 Very High Very High Very High
Repression 8 80.40 Quite High
Neurodegenerative Disease 46 61.92 Quite High
Spinal Cord Injury 38 5.00 Very Low Very Low Very Low
Spasticity 36 5.00 Very Low Very Low Very Low
Death 16 5.00 Very Low Very Low Very Low
Cocaine Dependence 14 5.00 Very Low Very Low Very Low
Congenital Anomalies 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The up-regulation of ATF4 has been associated with ischemia of both brain and spinal cord [49].
Regulation (regulation) of ATF4 in brain associated with ischemia and spinal cord
1) Confidence 0.43 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2900267 Disease Relevance 0.43 Pain Relevance 0.19
Thus, exposure to cocaine for a period of only 30 min can generate ROS sufficient to initiate ER stress, and result in up-regulation of ATF4 2.5 h later.
Regulation (regulation) of ATF4 associated with stress and cocaine
2) Confidence 0.29 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.27 Pain Relevance 0.63
Pretreatment of pregnant rats with cimetidine significantly inhibited the cocaine-induced up-regulation of ATF4 and the down-regulation of cyclin A (Figures 7C, 7D, S7C, S7D).
Regulation (regulation) of ATF4 associated with cocaine
3) Confidence 0.17 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.29 Pain Relevance 0.46
The up-regulation of ATF4 has been associated with ischemia of both brain and spinal cord [49].
Regulation (regulation) of ATF4 in spinal cord associated with ischemia and spinal cord
4) Confidence 0.15 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2900267 Disease Relevance 0.43 Pain Relevance 0.19

General Comments

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