INT241618

Context Info Confidence 0.43 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 4 Disease Relevance 1.41 Pain Relevance 1.46

plasma membrane (Atf4) cytoskeleton (Atf4) nucleus (Atf4) DNA binding (Atf4) microtubule organizing center (Atf4) cytoplasm (Atf4)

Anatomy Link Frequency spinal cord 1 brain 1 Atf4 (Rattus norvegicus)

Pain Link Frequency Relevance Heat cocaine 584 99.76 ischemia 2 98.96 Spinal cord 62 97.88 Central nervous system 26 5.00 Neurotransmitter 14 5.00 monoamine 6 5.00 Dopamine 6 5.00 GABAergic 6 5.00 cerebral cortex 4 5.00 Neurobehavioral 4 5.00

Disease Link Frequency Relevance Heat Stress 54 99.62 Injury 134 99.44 Cv Unclassified Under Development 2 98.96 Repression 8 80.40 Neurodegenerative Disease 46 61.92 Spinal Cord Injury 38 5.00 Spasticity 36 5.00 Death 16 5.00 Cocaine Dependence 14 5.00 Congenital Anomalies 10 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The up-regulation of ATF4 has been associated with ischemia of both brain and spinal cord [49].

Regulation (regulation) of ATF4 in brain associated with ischemia and spinal cord

1) Confidence 0.43 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2900267 Disease Relevance 0.43 Pain Relevance 0.19

Thus, exposure to cocaine for a period of only 30 min can generate ROS sufficient to initiate ER stress, and result in up-regulation of ATF4 2.5 h later.

Regulation (regulation) of ATF4 associated with stress and cocaine

2) Confidence 0.29 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.27 Pain Relevance 0.63

Pretreatment of pregnant rats with cimetidine significantly inhibited the cocaine-induced up-regulation of ATF4 and the down-regulation of cyclin A (Figures 7C, 7D, S7C, S7D).

Regulation (regulation) of ATF4 associated with cocaine

3) Confidence 0.17 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.29 Pain Relevance 0.46

The up-regulation of ATF4 has been associated with ischemia of both brain and spinal cord [49].

Regulation (regulation) of ATF4 in spinal cord associated with ischemia and spinal cord

4) Confidence 0.15 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2900267 Disease Relevance 0.43 Pain Relevance 0.19

General Comments

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