INT241620

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Context Info
Confidence 0.27
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.85
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Atf4) cytoskeleton (Atf4) nucleus (Atf4)
DNA binding (Atf4) microtubule organizing center (Atf4) cytoplasm (Atf4)
Atf4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cocaine 584 100.00 Very High Very High Very High
antagonist 2 79.44 Quite High
monoamine 6 67.00 Quite High
Neurotransmitter 4 57.92 Quite High
Central nervous system 20 5.00 Very Low Very Low Very Low
cerebral cortex 4 5.00 Very Low Very Low Very Low
Neurobehavioral 4 5.00 Very Low Very Low Very Low
sodium channel 2 5.00 Very Low Very Low Very Low
local anesthetic 2 5.00 Very Low Very Low Very Low
gABA 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 54 99.58 Very High Very High Very High
Gastroesophageal Reflux Disease 2 74.80 Quite High
Disease 4 72.88 Quite High
Ulcers 2 71.84 Quite High
Increased Venous Pressure Under Development 4 38.76 Quite Low
Cytomegalovirus Infection 8 34.96 Quite Low
Neurodegenerative Disease 44 28.80 Quite Low
Death 16 5.00 Very Low Very Low Very Low
Cocaine Dependence 14 5.00 Very Low Very Low Very Low
Congenital Anomalies 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This effect of cimetidine appeared to be mediated by prevention of N-oxidative metabolism of cocaine and consequent ER stress, as cimetidine also prevented the cocaine-induced increase in ATF4 (Figures 7C and S7C).
Negative_regulation (prevented) of Positive_regulation (increase) of ATF4 associated with stress and cocaine
1) Confidence 0.27 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.47 Pain Relevance 0.49
0.5 h after exposure to cocaine, preceding induction of ATF4 (Figure 6C).


Negative_regulation (preceding) of Positive_regulation (induction) of ATF4 associated with cocaine
2) Confidence 0.27 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.39 Pain Relevance 0.39

General Comments

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