INT241621

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.36
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cdkn1b) cell death (Cdkn1b) nucleus (Cdkn1b)
cell cycle (Cdkn1b) protein complex (Cdkn1b) response to stress (Cdkn1b)
Cdkn1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cocaine 292 99.82 Very High Very High Very High
Inflammation 2 98.68 Very High Very High Very High
cytokine 4 64.56 Quite High
Central nervous system 10 5.00 Very Low Very Low Very Low
monoamine 3 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
Neurobehavioral 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 2 98.68 Very High Very High Very High
Stress 36 61.84 Quite High
Cytomegalovirus Infection 4 58.84 Quite High
Adhesions 2 54.64 Quite High
Neurodegenerative Disease 22 5.00 Very Low Very Low Very Low
Death 9 5.00 Very Low Very Low Very Low
Shock 7 5.00 Very Low Very Low Very Low
Cocaine Dependence 7 5.00 Very Low Very Low Very Low
Congenital Anomalies 5 5.00 Very Low Very Low Very Low
Apoptosis 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The unique down-regulated pathways observed in 40% CR males included general groups such as cell cycle control (p27, Tert, CYCLIN, skp2e2f), immune/inflammatory function (classic, complement, comp) cell structure (cell_motil, edg1) and GPCR signaling (GPI7T, GPI7TRS, G_alpha_i).
Regulation (control) of p27 associated with inflammation
1) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607546 Disease Relevance 0.30 Pain Relevance 0.13
In addition, cocaine did not change levels of p21 and p27, CDK inhibitors that decrease transcription of cyclin A2 (Figure 6A) [33,34].
Neg (not) Regulation (change) of p27 associated with cocaine
2) Confidence 0.05 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.06 Pain Relevance 0.49

General Comments

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