INT241623

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.74
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 8.67
Pain Relevance 2.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Atf4) cytoskeleton (Atf4) nucleus (Atf4)
DNA binding (Atf4) microtubule organizing center (Atf4) cytoplasm (Atf4)
Anatomy Link Frequency
lung 4
cortex 1
Atf4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cocaine 876 99.14 Very High Very High Very High
ischemia 233 98.16 Very High Very High Very High
Inflammation 17 53.60 Quite High
Spinal cord 31 50.00 Quite Low
Neurotransmitter 11 44.52 Quite Low
sodium channel 3 35.76 Quite Low
local anesthetic 3 28.84 Quite Low
monoamine 9 18.16 Low Low
Central nervous system 33 5.00 Very Low Very Low Very Low
anesthesia 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 241 99.88 Very High Very High Very High
Stress 329 99.38 Very High Very High Very High
Lung Injury 56 98.22 Very High Very High Very High
Cv Unclassified Under Development 209 98.16 Very High Very High Very High
Reperfusion Injury 16 95.76 Very High Very High Very High
Injury 101 81.84 Quite High
Death 48 81.04 Quite High
Disease 14 72.64 Quite High
Neurodegenerative Disease 75 72.00 Quite High
Diabetes Mellitus 16 71.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, taurine interferes with the UPR, particularly with regard to the downregulation of ATF4 and XBP-1 expression, and subsequently reduces the level of the proapoptotic transcription factor CHOP.
Gene_expression (expression) of ATF4
1) Confidence 0.74 Published 2010 Journal Acta Orthopaedica Section Body Doc Link PMC2895349 Disease Relevance 0.71 Pain Relevance 0.07
Taurine pretreatment downregulated the expression of XBP-1, ATF4, and CHOP mRNA in lung tissues following limb ischemia reperfusion (M-W test, p = 0.017, p = 0.04, and p = 0.03, respectively) (Figure 3).


Gene_expression (expression) of ATF4 in lung associated with ischemia
2) Confidence 0.74 Published 2010 Journal Acta Orthopaedica Section Body Doc Link PMC2895349 Disease Relevance 0.81 Pain Relevance 0.24
In order to examine whether taurine reduced apoptosis induced by OFRs related to ER stress, we next examined regulation of the expression of XBP-1, ATF4, and CHOP by taurine.
Gene_expression (expression) of ATF4 associated with stress and apoptosis
3) Confidence 0.74 Published 2010 Journal Acta Orthopaedica Section Body Doc Link PMC2895349 Disease Relevance 0.51 Pain Relevance 0.07
This database is at present not fully annotated for all know transcriptions factors, and at the time of writing TRANSFAC contained motifs for 6 of the 34 transcription factors encoded by genes identified in the present study as differentially expressed (SP1, E2F1, FOXO1, ATF3, ATF4, MYC).
Gene_expression (expressed) of ATF4
4) Confidence 0.74 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2900267 Disease Relevance 0.25 Pain Relevance 0
Real-time PCR showed that XBP-1, ATF4, and CHOP mRNA levels in lung tissues of LIR rats drastically increased relative to those of control rats (M-W test, p = 0.027, p = 0.03, and p = 0.02, respectively).
Gene_expression (levels) of ATF4 in lung
5) Confidence 0.64 Published 2010 Journal Acta Orthopaedica Section Body Doc Link PMC2895349 Disease Relevance 0.74 Pain Relevance 0.23
Results Taurine statistically significantly attenuated lung injury following LIR, as shown by reduced malondialdehyde content, reduced cell apoptosis, and expression of activating transcription factor 4 (ATF4), X-box binding protein 1 (XBP1), and transcriptional activators of the CHOP gene.
Gene_expression (expression) of ATF4 in lung associated with lung injury and apoptosis
6) Confidence 0.58 Published 2010 Journal Acta Orthopaedica Section Abstract Doc Link PMC2895349 Disease Relevance 1.21 Pain Relevance 0.16
The protective effect of taurine was accompanied by reduced expression of the UPR-specific proapoptotic protein CHOP and its upstream transcription factors ATF4 and XBP-1 (Figure 4).


Gene_expression (expression) of ATF4
7) Confidence 0.58 Published 2010 Journal Acta Orthopaedica Section Body Doc Link PMC2895349 Disease Relevance 1.79 Pain Relevance 0.33
Results Taurine statistically significantly attenuated lung injury following LIR, as shown by reduced malondialdehyde content, reduced cell apoptosis, and expression of activating transcription factor 4 (ATF4), X-box binding protein 1 (XBP1), and transcriptional activators of the CHOP gene.
Gene_expression (expression) of activating transcription factor 4 in lung associated with lung injury and apoptosis
8) Confidence 0.58 Published 2010 Journal Acta Orthopaedica Section Abstract Doc Link PMC2895349 Disease Relevance 1.21 Pain Relevance 0.16
Taken together, these results demonstrate that taurine downregulates the levels of ATF4, XBP-1, and CHOP mRNA.
Gene_expression (levels) of ATF4
9) Confidence 0.58 Published 2010 Journal Acta Orthopaedica Section Body Doc Link PMC2895349 Disease Relevance 0.61 Pain Relevance 0.04
M cocaine for 30 min significantly up-regulated the expression of ATF4 at 3 h.
Gene_expression (expression) of ATF4 associated with cocaine
10) Confidence 0.43 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.31 Pain Relevance 0.52
and expression of ATF4.
Gene_expression (expression) of ATF4
11) Confidence 0.39 Published 2008 Journal PLoS Medicine Section Abstract Doc Link PMC2504032 Disease Relevance 0.21 Pain Relevance 0.56
To determine whether the protection afforded by cimetidine was due to the recovery of cocaine-induced down-regulation of cyclin A and mediation by ER stress, the effects of cimetidine on expression of ATF4 and cyclin A were also measured in prefrontal cortex of cocaine-treated fetuses.
Gene_expression (expression) of ATF4 in cortex associated with stress and cocaine
12) Confidence 0.39 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.30 Pain Relevance 0.47

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox