INT241624

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Context Info
Confidence 0.32
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.72
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Atf4) cytoskeleton (Atf4) nucleus (Atf4)
DNA binding (Atf4) microtubule organizing center (Atf4) cytoplasm (Atf4)
Atf4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cocaine 876 99.98 Very High Very High Very High
antagonist 3 79.44 Quite High
monoamine 9 66.12 Quite High
Neurotransmitter 6 57.04 Quite High
Dopamine 3 45.16 Quite Low
Central nervous system 30 12.60 Low Low
cerebral cortex 6 5.00 Very Low Very Low Very Low
Neurobehavioral 6 5.00 Very Low Very Low Very Low
sodium channel 3 5.00 Very Low Very Low Very Low
local anesthetic 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 81 99.14 Very High Very High Very High
Gastroesophageal Reflux Disease 3 74.80 Quite High
Disease 6 72.88 Quite High
Ulcers 3 71.84 Quite High
Cytomegalovirus Infection 12 54.44 Quite High
Increased Venous Pressure Under Development 6 37.88 Quite Low
Neurodegenerative Disease 66 28.80 Quite Low
Hyperoxia 3 20.72 Low Low
Repression 3 12.64 Low Low
Death 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An increase in ATF4 protein occurred as early as 1 h after 100 ?
Positive_regulation (occurred) of Positive_regulation (increase) of ATF4 protein
1) Confidence 0.32 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.11 Pain Relevance 0.52
Further, the P450 inhibitors SKF-525A and cimetidine, which have been shown to inhibit N-oxidative metabolism of cocaine, blocked cocaine-induced endogenous ROS generation, translational activation of ATF4, down-regulation of cyclin A, and proliferation inhibition in AF5 cells (Figure 6E–6H).
Positive_regulation (induced) of Positive_regulation (activation) of ATF4 associated with cocaine
2) Confidence 0.32 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.14 Pain Relevance 0.31
This effect of cimetidine appeared to be mediated by prevention of N-oxidative metabolism of cocaine and consequent ER stress, as cimetidine also prevented the cocaine-induced increase in ATF4 (Figures 7C and S7C).
Positive_regulation (induced) of Positive_regulation (increase) of ATF4 associated with stress and cocaine
3) Confidence 0.32 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.46 Pain Relevance 0.48

General Comments

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