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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.83
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Atf4) cytoskeleton (Atf4) nucleus (Atf4)
DNA binding (Atf4) microtubule organizing center (Atf4) cytoplasm (Atf4)
Atf4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cocaine 292 99.42 Very High Very High Very High
ischemia 29 81.92 Quite High
Inflammation 2 54.32 Quite High
Neurotransmitter 2 41.68 Quite Low
sodium channel 1 36.32 Quite Low
local anesthetic 1 29.40 Quite Low
monoamine 3 18.16 Low Low
Central nervous system 10 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
Neurobehavioral 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 58 99.62 Very High Very High Very High
Apoptosis 32 98.88 Very High Very High Very High
Cv Unclassified Under Development 26 81.92 Quite High
Injury 5 73.52 Quite High
Neurodegenerative Disease 23 72.56 Quite High
Increased Venous Pressure Under Development 2 67.44 Quite High
Microcephaly 1 56.40 Quite High
INFLAMMATION 2 54.32 Quite High
Adult Respiratory Distress Syndrome 1 47.56 Quite Low
Lung Injury 7 5.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to examine whether taurine reduced apoptosis induced by OFRs related to ER stress, we next examined regulation of the expression of XBP-1, ATF4, and CHOP by taurine.
Spec (examined) Regulation (regulation) of Gene_expression (expression) of ATF4 associated with stress and apoptosis
1) Confidence 0.43 Published 2010 Journal Acta Orthopaedica Section Body Doc Link PMC2895349 Disease Relevance 0.52 Pain Relevance 0.07
M cocaine for 30 min significantly up-regulated the expression of ATF4 at 3 h.
Regulation (regulated) of Gene_expression (expression) of ATF4 associated with cocaine
2) Confidence 0.29 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.31 Pain Relevance 0.52

General Comments

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