INT24163

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Context Info
Confidence 0.59
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 2.90
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Prss3) extracellular space (Prss3) extracellular region (Prss3)
Anatomy Link Frequency
pancreas 2
Prss3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 21 95.68 Very High Very High Very High
fibrosis 3 95.52 Very High Very High Very High
Inflammation 7 91.76 High High
cytokine 1 60.48 Quite High
alcohol 10 59.60 Quite High
Inflammatory response 2 6.60 Low Low
Cholecystokinin 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 2 99.90 Very High Very High Very High
Pancreatitis 64 99.00 Very High Very High Very High
Injury 4 97.28 Very High Very High Very High
Fibrosis 3 95.52 Very High Very High Very High
INFLAMMATION 9 91.76 High High
Ulcers 4 90.32 High High
Appetite Loss 2 89.80 High High
Shock 1 87.04 High High
Stress 7 77.12 Quite High
Alcoholic Pancreatitis 6 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Trypsinogen and elastase secreted into pancreatic juice were upregulated after a protein-deficient diet relative to a control diet.
Positive_regulation (upregulated) of Trypsinogen
1) Confidence 0.59 Published 2000 Journal Pancreas Section Abstract Doc Link 10975713 Disease Relevance 0.23 Pain Relevance 0.11
Adaptive responses of the pancreas have shown that anionic proteases (e.g., trypsinogen) are upregulated during protein deprivation.
Positive_regulation (upregulated) of trypsinogen in pancreas
2) Confidence 0.40 Published 2000 Journal Pancreas Section Abstract Doc Link 10975713 Disease Relevance 0.25 Pain Relevance 0.13
Hyperamylasaemia, pancreatic oedema and activation of trypsinogen in the pancreatic tissue, as well as subcellular redistribution of the lysosomal enzyme, cathepsin B, from the lysosomal fraction to the zymogen fraction, were prevented by infusion of 20 mg/kg.h cetraxate for 2 h before caerulein infusion and throughout the 3.5 h of caerulein infusion (5 micrograms/kg.h).
Positive_regulation (activation) of trypsinogen associated with pressure and volume under development
3) Confidence 0.37 Published 1994 Journal J. Int. Med. Res. Section Abstract Doc Link 8020637 Disease Relevance 0.51 Pain Relevance 0.05
The results indicate that cetraxate plays its protective roles against pancreatitis by inhibiting the redistribution of lysosomal enzyme and by activation of trypsinogen; such activities may be clinically useful in preventing pancreatic injuries, particularly in patients with chronic pancreatitis.
Positive_regulation (activation) of trypsinogen associated with injury, pancreatitis and chronic pancreatitis
4) Confidence 0.37 Published 1994 Journal J. Int. Med. Res. Section Abstract Doc Link 8020637 Disease Relevance 0.67 Pain Relevance 0.10
RESULTS: Our data revealed that the ratio of trypsinogen to that of the protective pancreas-specific trypsin inhibitor was elevated upon cigarette smoke exposure.
Positive_regulation (elevated) of trypsinogen in pancreas
5) Confidence 0.17 Published 2006 Journal Pancreas Section Body Doc Link 17079941 Disease Relevance 0 Pain Relevance 0
In the pancreatic tissue of animals fed ethanol, total protein, trypsinogen (and free trypsin) were increased and amylase was decreased.
Positive_regulation (increased) of trypsinogen
6) Confidence 0.04 Published 1987 Journal Int. J. Pancreatol. Section Abstract Doc Link 2447206 Disease Relevance 0.32 Pain Relevance 0.14
Using a newly developed PSTI-I ELISA, we can show that the PSTI-I/trypsinogen ratio is not decreased but rather increased in WBN/Kob rats compared to healthy Wistar rats.
Positive_regulation (increased) of trypsinogen
7) Confidence 0.02 Published 2002 Journal Pancreatology Section Body Doc Link 12123090 Disease Relevance 0.09 Pain Relevance 0
M quercetin completely blocked culture-induced upregulation of HSP70 expression and restored the culture-dependent loss of trypsinogen activation in the cerulein-induced pancreatitis.
Positive_regulation (activation) of trypsinogen associated with pancreatitis
8) Confidence 0.01 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872306 Disease Relevance 0.83 Pain Relevance 0.12

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