INT24166

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Context Info
Confidence 0.80
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 40
Total Number 40
Disease Relevance 9.11
Pain Relevance 10.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 2
bowel 2
gut 2
neurons 2
jejunum 2
Mln (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 22 100.00 Very High Very High Very High
Serotonin 17 100.00 Very High Very High Very High
Cholecystokinin 16 100.00 Very High Very High Very High
Neuropeptide 8 100.00 Very High Very High Very High
cerebral cortex 2 99.92 Very High Very High Very High
spastic colon 17 99.84 Very High Very High Very High
Enkephalin 11 99.70 Very High Very High Very High
Morphine 45 99.60 Very High Very High Very High
opiate 9 99.60 Very High Very High Very High
antagonist 8 99.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Functional Bowel Disorder 11 99.84 Very High Very High Very High
Gastric Motility Disorder 25 99.08 Very High Very High Very High
Injury 188 98.96 Very High Very High Very High
Carcinoid 11 98.80 Very High Very High Very High
Shock 5 98.64 Very High Very High Very High
Pancreatitis 11 98.12 Very High Very High Very High
Disease 14 98.08 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

10 97.44 Very High Very High Very High
Apoptosis 122 96.52 Very High Very High Very High
Congenital Anomalies 7 96.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tissue section autoradiography in the antrum revealed that specific labeled motilin binding sites were localized in the circular muscle layer and myenteric plexus, and could be reduced in the presence of an excess of EM574.
Localization (localized) of motilin in muscle
1) Confidence 0.80 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9088872 Disease Relevance 0 Pain Relevance 0.19
Both phenylephrine and octreotide decreased the release of motilin stimulated by carbachol in a jejunal segment pretreated and denervated with tetrodotoxin.
Localization (release) of motilin associated with tetrodotoxin
2) Confidence 0.79 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9038869 Disease Relevance 0 Pain Relevance 0.65
Therefore, a revised model for the regulation of motilin release from M cells of intestinal mucosa can now be proposed.
Localization (release) of motilin in M cells
3) Confidence 0.79 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9038869 Disease Relevance 0 Pain Relevance 0.64
Regulation of motilin release: studies with ex vivo perfused canine jejunum.
Localization (release) of motilin in jejunum
4) Confidence 0.79 Published 1997 Journal Am. J. Physiol. Section Title Doc Link 9038869 Disease Relevance 0 Pain Relevance 0.47
The secretion of motilin in the effluent venous system of the isolated intestine was measured by radioimmunoassay in response to various pharmacological agents injected intra-arterially.
Localization (secretion) of motilin in intestine
5) Confidence 0.79 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9038869 Disease Relevance 0 Pain Relevance 0.34
Carcinoid tumors are known to contain and secrete several biologically active substances such as serotonin, histamine, prostaglandins, and tachykinins, which are likely to cause disturbances of intestinal secretion and motility, which in turn might release motilin from the motilin-containing cells of the small intestine.
Localization (release) of motilin in small intestine associated with carcinoid and serotonin
6) Confidence 0.77 Published 1987 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 2447632 Disease Relevance 0.86 Pain Relevance 0.13
We have studied 73 patients with metastatic carcinoid tumors with regard to stool frequency and plasma concentration of motilin and neuropeptide K (NPK) and diurnal urinary excretion of 5-hydroxyindoleacetic acid (5-HIAA).
Localization (excretion) of motilin in plasma associated with carcinoid and neuropeptide
7) Confidence 0.72 Published 1987 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 2447632 Disease Relevance 1.10 Pain Relevance 0.14
The regulatory process of motilin release was studied in segments of canine jejunum isolated and perfused ex vivo.
Localization (release) of motilin in jejunum
8) Confidence 0.69 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9038869 Disease Relevance 0 Pain Relevance 0.20
Muscarinie agonist and antagonist, respectively, increased and decreased the release of motilin.
Localization (release) of motilin associated with antagonist and agonist
9) Confidence 0.69 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9038869 Disease Relevance 0 Pain Relevance 0.49
Bombesin and morphine also increased the release of motilin.
Localization (release) of motilin associated with morphine
10) Confidence 0.69 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9038869 Disease Relevance 0 Pain Relevance 0.57
An in vitro model was developed to study the regulation of motilin release from its endocrine-producing cell.
Localization (release) of motilin
11) Confidence 0.67 Published 1993 Journal Peptides Section Abstract Doc Link 8483799 Disease Relevance 0 Pain Relevance 0.10
Carbachol dose-dependently stimulated the release of motilin from its producing cell.
Localization (release) of motilin
12) Confidence 0.67 Published 1993 Journal Peptides Section Abstract Doc Link 8483799 Disease Relevance 0 Pain Relevance 0.21
Bombesin, morphine, and erythromycin, recognized stimulants for motilin release in vivo, failed to influence the secretion of motilin in vitro.
Localization (secretion) of motilin associated with morphine
13) Confidence 0.67 Published 1993 Journal Peptides Section Abstract Doc Link 8483799 Disease Relevance 0 Pain Relevance 0.23
From the motilin-enriched cell preparation, the release of motilin was determined under stimulation with various agents.
Localization (release) of motilin
14) Confidence 0.67 Published 1993 Journal Peptides Section Abstract Doc Link 8483799 Disease Relevance 0 Pain Relevance 0.19
Bombesin, morphine, and erythromycin, recognized stimulants for motilin release in vivo, failed to influence the secretion of motilin in vitro.
Localization (release) of motilin associated with morphine
15) Confidence 0.67 Published 1993 Journal Peptides Section Abstract Doc Link 8483799 Disease Relevance 0 Pain Relevance 0.22
Although peripheral actions have been shown for the brain-gut peptide, motilin, its localization in the CNS of mammals suggests some physiological role at this site.
Localization (localization) of motilin in gut
16) Confidence 0.65 Published 1984 Journal Life Sci. Section Abstract Doc Link 6547500 Disease Relevance 0.08 Pain Relevance 0.28
In pentobarbital-treated animals, regardless of the extent of heparinization, consistent translocation to both MLN and distant organs occurred when shock was prolonged for 90 min, and assessment of translocation was made 24 hr after reinfusion of shed blood.
Localization (translocation) of MLN in blood associated with shock
17) Confidence 0.62 Published 1993 Journal Circ. Shock Section Abstract Doc Link 8348683 Disease Relevance 0.44 Pain Relevance 0.08
Covariation of plasma ghrelin and motilin in irritable bowel syndrome.
Localization (Covariation) of motilin in bowel associated with spastic colon
18) Confidence 0.60 Published 2010 Journal Peptides Section Title Doc Link 20338210 Disease Relevance 0.18 Pain Relevance 0.52
Cholinergic regulation of motilin release from isolated canine intestinal cells.
Localization (release) of motilin in intestinal cells
19) Confidence 0.59 Published 1993 Journal Peptides Section Title Doc Link 8483799 Disease Relevance 0 Pain Relevance 0.18
These results suggest that muscarinic receptors are present on the motilin cell membrane and that acetylcholine is a major regulator of motilin release.
Localization (release) of motilin
20) Confidence 0.59 Published 1993 Journal Peptides Section Abstract Doc Link 8483799 Disease Relevance 0 Pain Relevance 0.21

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