INT241664

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.33
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PRB3) biological_process (PRB3)
Anatomy Link Frequency
neural 1
PRB3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cocaine 584 97.68 Very High Very High Very High
local anesthetic 2 30.32 Quite Low
sodium channel 2 16.32 Low Low
Central nervous system 20 5.00 Very Low Very Low Very Low
monoamine 6 5.00 Very Low Very Low Very Low
cerebral cortex 4 5.00 Very Low Very Low Very Low
Neurotransmitter 4 5.00 Very Low Very Low Very Low
Neurobehavioral 4 5.00 Very Low Very Low Very Low
gABA 2 5.00 Very Low Very Low Very Low
Dopamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperoxia 2 99.82 Very High Very High Very High
Repression 2 97.32 Very High Very High Very High
Stress 54 82.72 Quite High
Intellectual Impairment 2 50.32 Quite High
Cocaine Dependence 14 42.12 Quite Low
Congenital Anomalies 10 40.20 Quite Low
Pre-term Labor 2 28.16 Quite Low
Toxicity 8 25.00 Low Low
Apoptosis 6 25.00 Low Low
Reprotox - General 1 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When the researchers investigated the effects of cocaine on AF5 cells (rat neural progenitor cells that grow indefinitely in the laboratory), they found that concentrations of cocaine similar to those measured in fetal brains after maternal drug exposure inhibited the proliferation of AF5 cells by blocking the “G1-to-S transition.”
Negative_regulation (blocking) of G1 in neural associated with cocaine
1) Confidence 0.08 Published 2008 Journal PLoS Medicine Section Abstract Doc Link PMC2504032 Disease Relevance 0.05 Pain Relevance 0.32
Activation of the p53-p21 pathway has been implicated in hyperoxia-induced inhibition of G1/S progression, through suppression of CDK activity and subsequent repression of cyclin A2 transcription and inactivation of PCNA [34,49].
Negative_regulation (inhibition) of G1 associated with repression and hyperoxia
2) Confidence 0.06 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.28 Pain Relevance 0.45

General Comments

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