INT241667

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Context Info
Confidence 0.32
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CCNA2) mitosis (CCNA2) nucleus (CCNA2)
cell division (CCNA2) cytoplasm (CCNA2)
Anatomy Link Frequency
brains 2
CCNA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cocaine 292 100.00 Very High Very High Very High
Central nervous system 10 5.00 Very Low Very Low Very Low
monoamine 3 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Neurobehavioral 2 5.00 Very Low Very Low Very Low
sodium channel 1 5.00 Very Low Very Low Very Low
local anesthetic 1 5.00 Very Low Very Low Very Low
gABA 1 5.00 Very Low Very Low Very Low
Dopamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 4 35.36 Quite Low
Stress 27 25.00 Low Low
Cocaine Dependence 7 25.00 Low Low
Congenital Anomalies 5 25.00 Low Low
Apoptosis 3 25.00 Low Low
Reprotox - General 1 1 25.00 Low Low
Intellectual Impairment 1 25.00 Low Low
Pre-term Labor 1 25.00 Low Low
Neurodegenerative Disease 22 5.00 Very Low Very Low Very Low
Death 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, treatment of pregnant rats with cimetidine (which inhibits the action of cytochrome P450) counteracted both the inhibition of neural progenitor cell proliferation and the cyclin A2 down-regulation that cocaine exposure induced in the brains of their unborn pups.


Positive_regulation (induced) of Regulation (regulation) of cyclin A2 in brains associated with cocaine
1) Confidence 0.32 Published 2008 Journal PLoS Medicine Section Abstract Doc Link PMC2504032 Disease Relevance 0 Pain Relevance 0.35

General Comments

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