INT241668

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Context Info
Confidence 0.27
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.44
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CCNA2) mitosis (CCNA2) nucleus (CCNA2)
cell division (CCNA2) cytoplasm (CCNA2)
CCNA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cocaine 876 99.14 Very High Very High Very High
local anesthetic 3 38.64 Quite Low
sodium channel 3 24.64 Low Low
Central nervous system 30 5.00 Very Low Very Low Very Low
monoamine 9 5.00 Very Low Very Low Very Low
cerebral cortex 6 5.00 Very Low Very Low Very Low
Neurotransmitter 6 5.00 Very Low Very Low Very Low
Neurobehavioral 6 5.00 Very Low Very Low Very Low
gABA 3 5.00 Very Low Very Low Very Low
Dopamine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 3 100.00 Very High Very High Very High
Hyperoxia 3 98.16 Very High Very High Very High
Stress 81 79.40 Quite High
Cytomegalovirus Infection 12 57.48 Quite High
Neurodegenerative Disease 66 5.00 Very Low Very Low Very Low
Death 24 5.00 Very Low Very Low Very Low
Cocaine Dependence 21 5.00 Very Low Very Low Very Low
Congenital Anomalies 15 5.00 Very Low Very Low Very Low
Toxicity 12 5.00 Very Low Very Low Very Low
Apoptosis 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, cocaine did not change levels of p21 and p27, CDK inhibitors that decrease transcription of cyclin A2 (Figure 6A) [33,34].
Negative_regulation (decrease) of Transcription (transcription) of cyclin A2 associated with cocaine
1) Confidence 0.27 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.06 Pain Relevance 0.52
Activation of the p53-p21 pathway has been implicated in hyperoxia-induced inhibition of G1/S progression, through suppression of CDK activity and subsequent repression of cyclin A2 transcription and inactivation of PCNA [34,49].
Negative_regulation (repression) of Transcription (transcription) of cyclin A2 associated with repression and hyperoxia
2) Confidence 0.27 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.33 Pain Relevance 0.46
In addition, cocaine did not change levels of p21 and p27, CDK inhibitors that decrease transcription of cyclin A2 (Figure 6A) [33,34].
Negative_regulation (inhibitors) of Transcription (transcription) of cyclin A2 associated with cocaine
3) Confidence 0.27 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.06 Pain Relevance 0.52

General Comments

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