INT241672

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.56
Pain Relevance 1.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CCNA2) mitosis (CCNA2) nucleus (CCNA2)
cell division (CCNA2) cytoplasm (CCNA2)
Anatomy Link Frequency
neurons 1
astrocytes 1
microglia 1
CCNA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cocaine 876 99.98 Very High Very High Very High
Central nervous system 30 84.08 Quite High
cINOD 1 73.80 Quite High
monoamine 9 5.00 Very Low Very Low Very Low
cerebral cortex 6 5.00 Very Low Very Low Very Low
Neurotransmitter 6 5.00 Very Low Very Low Very Low
Neurobehavioral 6 5.00 Very Low Very Low Very Low
sodium channel 3 5.00 Very Low Very Low Very Low
local anesthetic 3 5.00 Very Low Very Low Very Low
gABA 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 13 96.16 Very High Very High Very High
Malignant Neoplastic Disease 1 88.80 High High
Stress 81 86.72 High High
Gliosis 3 77.84 Quite High
INFLAMMATION 3 73.56 Quite High
Hyperplasia 3 71.12 Quite High
Liver Cancer 1 58.72 Quite High
Cirrhosis 2 56.32 Quite High
Cleidocranial Dysplasia 1 48.24 Quite Low
Hepatitis C Virus Infection 2 47.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to progenitor cells, the cyclin A2 transcript was increased by cocaine in human astrocytes.
Positive_regulation (increased) of cyclin A2 in astrocytes associated with cocaine
1) Confidence 0.44 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.31 Pain Relevance 0.49
The upregulation of CCNA2 and downregulation of EGR1 might thus play a key role in the dysregulation of normal growth in HCC carcinogenesis [56].
Positive_regulation (upregulation) of CCNA2 associated with hepatocellular cancer
2) Confidence 0.40 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2900289 Disease Relevance 0.69 Pain Relevance 0.07
Cocaine-induced cyclin A2 down-regulation was observed in human neural progenitor and A2B5+ progenitor cells, but not in human neurons and microglia.
Positive_regulation (induced) of cyclin A2 in microglia associated with cocaine
3) Confidence 0.32 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.27 Pain Relevance 0.50
Cocaine-induced cyclin A2 down-regulation was observed in human neural progenitor and A2B5+ progenitor cells, but not in human neurons and microglia.
Positive_regulation (induced) of cyclin A2 in neurons associated with cocaine
4) Confidence 0.11 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.27 Pain Relevance 0.50

General Comments

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