INT241673

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Context Info
Confidence 0.79
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.06
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GDNF) extracellular region (GDNF)
GDNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 24 95.40 Very High Very High Very High
Arthritis 12 94.92 High High
Osteoarthritis 60 91.92 High High
cerebral cortex 2 71.36 Quite High
Hyperalgesia 14 58.88 Quite High
withdrawal 12 50.56 Quite High
cytokine 46 50.32 Quite High
rheumatoid arthritis 4 39.52 Quite Low
cocaine 292 33.96 Quite Low
metalloproteinase 10 14.52 Low Low
Disease Link Frequency Relevance Heat
Pain 26 95.40 Very High Very High Very High
Arthritis 10 94.92 High High
Osteoarthritis 84 93.68 High High
Cytomegalovirus Infection 4 79.28 Quite High
Hyperalgesia 22 58.88 Quite High
Osteophyte 2 45.88 Quite Low
Rheumatoid Arthritis 4 39.52 Quite Low
INFLAMMATION 16 13.76 Low Low
Stress 27 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
(Cell Signaling), cyclin A, ATF1, ATF2, ATF3, ATF4, phospho-CREB (Ser-133), CREB, JunB, JunD, c-Jun, c-Fos, p21, and p27 (Santa Cruz Biotechnology).
Phosphorylation (phospho) of ATF1
1) Confidence 0.79 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.08 Pain Relevance 0.04
Phosphorylated ATF2 was detected using a phosphoATF2 (Thr71) specific primary antibody (Cell Signaling) that was then followed by ALP-conjugated goat anti-rabbit IgG (Jackson Immune Research).
Phosphorylation (Phosphorylated) of ATF2
2) Confidence 0.61 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2612656 Disease Relevance 0.30 Pain Relevance 0.18
P38 kinase activity was evaluated in a kinase assay by measuring the amount of phosphorylated substrate ATF2 using a phosphoATF2 (Thr71) specific primary antibody and an alkaline phosphate coupled secondary antibody and measuring the OD at 405 nm.
Phosphorylation (phosphorylated) of ATF2
3) Confidence 0.61 Published 2008 Journal J Inflamm (Lond) Section Abstract Doc Link PMC2612656 Disease Relevance 0.67 Pain Relevance 0.39

General Comments

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