INT241679

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.46
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (EIF2AK3, Atf4) endoplasmic reticulum (EIF2AK3) DNA binding (Atf4)
microtubule organizing center (Atf4) response to stress (EIF2AK3) plasma membrane (Atf4)
Anatomy Link Frequency
reticulum 1
EIF2AK3 (Homo sapiens)
Atf4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cocaine 292 94.84 High High
Central nervous system 10 5.00 Very Low Very Low Very Low
monoamine 3 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Neurobehavioral 2 5.00 Very Low Very Low Very Low
sodium channel 1 5.00 Very Low Very Low Very Low
local anesthetic 1 5.00 Very Low Very Low Very Low
gABA 1 5.00 Very Low Very Low Very Low
Dopamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 27 98.72 Very High Very High Very High
Cytomegalovirus Infection 4 26.48 Quite Low
Neurodegenerative Disease 22 5.00 Very Low Very Low Very Low
Death 8 5.00 Very Low Very Low Very Low
Cocaine Dependence 7 5.00 Very Low Very Low Very Low
Congenital Anomalies 5 5.00 Very Low Very Low Very Low
Toxicity 4 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Newborn Drug Withdrawal Syndrome 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-ATF4 pathway is activated by PERK, an endoplasmic reticulum (ER) stress sensor protein [35,36].
PERK Positive_regulation (activated) of ATF4 in reticulum associated with stress
1) Confidence 0.06 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.46 Pain Relevance 0.40

General Comments

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