INT241721

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Context Info
Confidence 0.50
First Reported 2008
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 1.39
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adora1) endoplasmic reticulum (Adora1) plasma membrane (Adora1)
signal transducer activity (Adora1)
Anatomy Link Frequency
atrium 4
heart 2
Adora1 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 355 100.00 Very High Very High Very High
ischemia 193 74.92 Quite High
Central nervous system 21 61.00 Quite High
agonist 31 32.76 Quite Low
antagonist 23 19.12 Low Low
Eae 6 15.60 Low Low
Inflammation 70 5.00 Very Low Very Low Very Low
cytokine 10 5.00 Very Low Very Low Very Low
medulla 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heart Rate Under Development 57 99.56 Very High Very High Very High
Hypoxia 25 79.60 Quite High
Cv Unclassified Under Development 186 74.92 Quite High
Targeted Disruption 18 66.88 Quite High
Infection 3 62.32 Quite High
Necrosis 10 50.80 Quite High
Body Weight 6 30.84 Quite Low
INFLAMMATION 64 5.00 Very Low Very Low Very Low
Injury 25 5.00 Very Low Very Low Very Low
Acute Renal Failure 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Genetic deletion of the A1AR abolishes adenosine-induced slowing of the heart-rate
Positive_regulation (induced) of Transcription (deletion) of A1AR in heart associated with adenocard
1) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2727950 Disease Relevance 0.26 Pain Relevance 0.51
The A1AR promoter is highly active in the atrium [32], leading to high A1AR mRNA levels [31].
Positive_regulation (high) of Transcription (levels) of A1AR in atrium
2) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2727950 Disease Relevance 0.30 Pain Relevance 0.37
The A1AR promoter is highly active in the atrium [32], leading to high A1AR mRNA levels [31].
Positive_regulation (leading) of Transcription (levels) of A1AR in atrium
3) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2727950 Disease Relevance 0.30 Pain Relevance 0.38
In contrast, mRNA levels for the A1AR, A2AAR, and A3AR remained unchanged following 60, 120, or 240 min of IP (Figure 9A, 9B, and 9D).
Neg (unchanged) Positive_regulation (unchanged) of Transcription (levels) of A1AR
4) Confidence 0.42 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504049 Disease Relevance 0.27 Pain Relevance 0.07
In contrast, mRNA levels for the A1AR, A2AAR, and A3AR remained unchanged following 60, 120, or 240 min of IP (Figure 9A, 9B, and 9D).
Positive_regulation (following) of Transcription (levels) of A1AR
5) Confidence 0.42 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504049 Disease Relevance 0.27 Pain Relevance 0.07

General Comments

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