INT241724

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Context Info
Confidence 0.75
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.21
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adora2b) plasma membrane (Adora2b) signal transducer activity (Adora2b)
Adora2b (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 78 100.00 Very High Very High Very High
ischemia 95 99.44 Very High Very High Very High
fibrosis 9 97.82 Very High Very High Very High
adenocard 266 97.04 Very High Very High Very High
antagonist 46 95.52 Very High Very High Very High
agonist 194 86.84 High High
Inflammatory mediators 3 41.68 Quite Low
Inflammation 59 26.64 Quite Low
Opioid 7 16.40 Low Low
Pain 6 10.32 Low Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 102 99.44 Very High Very High Very High
Cystic Fibrosis 9 97.82 Very High Very High Very High
Asthma 6 89.12 High High
Pulmonary Disease 6 88.24 High High
Necrosis 8 77.52 Quite High
Reprotox - General 1 6 64.32 Quite High
Cancer 7 59.92 Quite High
Diabetes Mellitus 12 58.16 Quite High
Body Weight 3 57.56 Quite High
INFLAMMATION 59 41.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, these studies provide strong rationale for therapeutically targeting the A2BAR during renal ischemia.


Localization (targeting) of A2BAR associated with ischemia
1) Confidence 0.75 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504049 Disease Relevance 0.45 Pain Relevance 0.16
The 4-p-OH-phenyl derivative (49, LUF5834) is of particular interest, thanks to its high potency at the hA2B AR (EC50?
Localization (potency) of A2B associated with potency
2) Confidence 0.73 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583210 Disease Relevance 0 Pain Relevance 0.21
Substitution of the indole moiety with other (hetero)aryl nuclei, such as phenyl, naphthyl, thiophene, pyrrole, benzoimidazole or benzotriazole, did not succeed in enhancing A2B AR potency.
Localization (potency) of A2B associated with potency
3) Confidence 0.45 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583210 Disease Relevance 0.06 Pain Relevance 0.37
The stimulated secretory response has been identified to be the result of A2B AR activation and was lost in a cell line derived from a cystic fibrosis patient with a defect in ion transport at CFTR, implicating this ion channel as the one responsible for the A2B AR-mediated Cl- secretion [31].


Localization (secretion) of A2B associated with fibrosis and cystic fibrosis
4) Confidence 0.43 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583210 Disease Relevance 0.70 Pain Relevance 0.41

General Comments

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