INT241733

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.84
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Nt5e) cytoplasm (Nt5e)
Anatomy Link Frequency
epithelial cells 1
Nt5e (Mus musculus)
Pain Link Frequency Relevance Heat
Antinociceptive 44 98.28 Very High Very High Very High
COX2 7 98.16 Very High Very High Very High
adenocard 113 97.68 Very High Very High Very High
ischemia 95 95.28 Very High Very High Very High
Inflammation 74 88.56 High High
Antihyperalgesic 8 86.48 High High
antiallodynic 8 83.92 Quite High
IPN 8 76.24 Quite High
Neuropathic pain 6 71.36 Quite High
intrathecal 8 58.56 Quite High
Disease Link Frequency Relevance Heat
Infection 97 98.76 Very High Very High Very High
Respiratory Syncytial Virus 99 98.36 Very High Very High Very High
Cv Unclassified Under Development 90 95.28 Very High Very High Very High
Pneumonia 15 92.88 High High
INFLAMMATION 77 88.56 High High
Nociception 10 81.04 Quite High
Sepsis 5 77.88 Quite High
Bacteremia 2 77.44 Quite High
Inflammatory Pain 8 76.24 Quite High
Hypoxia 35 75.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
M), a selective inhibitor of NT5E. mNT5E exhibited a dose-dependent thermal antinociceptive effect that lasted for two days when injected intrathecally in wild-type mice.
Negative_regulation (inhibitor) of NT5E associated with antinociceptive
1) Confidence 0.40 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2874211 Disease Relevance 0.44 Pain Relevance 0.75
Recombinant mNT5E was also inhibited by ?
Negative_regulation (inhibited) of mNT5E
2) Confidence 0.35 Published 2010 Journal Mol Pain Section Body Doc Link PMC2874211 Disease Relevance 0 Pain Relevance 0.14
To confirm the extracellular nature of these findings, we repeated this experiment in previously characterized mice deficient of cd73 [23,52].
Negative_regulation (deficient) of cd73
3) Confidence 0.29 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504049 Disease Relevance 0.22 Pain Relevance 0.56
Thus, we measured transcript levels of CD73 [62], VEGF [63], Fibronectin1 (FN1) [64] and COX2 [65] after 24 h of RSV infection of A549 pulmonary epithelial cells using different RSV infection doses (MOI1-5).
Negative_regulation (levels) of CD73 in epithelial cells associated with cox2, infection and respiratory syncytial virus
4) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.79 Pain Relevance 0.08
However, whether Ybt can compensate for the loss of Ent bound by Lcn2 is unknown.
Negative_regulation (loss) of Ent
5) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.40 Pain Relevance 0.04

General Comments

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