INT241737

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Context Info
Confidence 0.72
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.89
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adora1) endoplasmic reticulum (Adora1) plasma membrane (Adora1)
signal transducer activity (Adora1)
Anatomy Link Frequency
atrium 1
heart 1
Adora1 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 251 99.56 Very High Very High Very High
cocaine 42 99.24 Very High Very High Very High
Eae 11 86.44 High High
ischemia 97 74.92 Quite High
Central nervous system 14 60.36 Quite High
agonist 19 32.12 Quite Low
antagonist 20 19.12 Low Low
Inflammation 36 5.00 Very Low Very Low Very Low
Dopamine 5 5.00 Very Low Very Low Very Low
Nucleus accumbens 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heart Rate Under Development 38 99.56 Very High Very High Very High
Hypoxia 14 75.92 Quite High
Cv Unclassified Under Development 94 74.92 Quite High
Attention Deficit Hyperactivity Disorder 7 73.52 Quite High
Targeted Disruption 11 66.88 Quite High
Infection 2 60.08 Quite High
Necrosis 5 50.80 Quite High
Body Weight 3 30.84 Quite Low
INFLAMMATION 33 5.00 Very Low Very Low Very Low
Injury 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The A1AR promoter is highly active in the atrium [32], leading to high A1AR mRNA levels [31].
Transcription (levels) of A1AR in atrium
1) Confidence 0.72 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2727950 Disease Relevance 0.29 Pain Relevance 0.37
Genetic deletion of the A1AR abolishes adenosine-induced slowing of the heart-rate
Transcription (deletion) of A1AR in heart associated with adenocard
2) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2727950 Disease Relevance 0.26 Pain Relevance 0.51
The same phenomenon was also found in the female offspring of the A1R Hz mothers after the cocaine stimulation (interaction mother's genotype p?
Transcription (offspring) of A1R Hz associated with cocaine
3) Confidence 0.67 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597749 Disease Relevance 0.07 Pain Relevance 0.37
In contrast, mRNA levels for the A1AR, A2AAR, and A3AR remained unchanged following 60, 120, or 240 min of IP (Figure 9A, 9B, and 9D).
Transcription (levels) of A1AR
4) Confidence 0.64 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504049 Disease Relevance 0.27 Pain Relevance 0.07

General Comments

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