INT241748

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Context Info
Confidence 0.21
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.39
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CCR5, CD4) endosome (CCR5) signal transduction (CD4)
cell adhesion (CD4) enzyme binding (CD4) cell-cell signaling (CCR5)
CCR5 (Homo sapiens)
CD4 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 32 100.00 Very High Very High Very High
chemokine 22 39.76 Quite Low
iatrogenic 1 29.20 Quite Low
Bioavailability 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Parenteral administration 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 1 89.92 High High
Adenocarcinoma 1 88.96 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 72 80.24 Quite High
Immunodeficiency 3 65.60 Quite High
Infection 21 21.12 Low Low
Sprains And Strains 11 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Hepatotoxicity 3 5.00 Very Low Very Low Very Low
Hepatitis 2 5.00 Very Low Very Low Very Low
Yersinia Infection 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This finding has generated interest in the possibility that maraviroc, or CCR5 antagonists in general, may have an effect on elevating CD4 cell counts independent of antiviral activity.


CCR5 Regulation (effect) of CD4 associated with antagonist
1) Confidence 0.21 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504054 Disease Relevance 0.39 Pain Relevance 0.11

General Comments

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