INT241748

Context Info Confidence 0.21 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.39 Pain Relevance 0.11

plasma membrane (CCR5, CD4) endosome (CCR5) signal transduction (CD4) cell adhesion (CD4) enzyme binding (CD4) cell-cell signaling (CCR5)

CCR5 (Homo sapiens) CD4 (Homo sapiens)

Pain Link Frequency Relevance Heat antagonist 32 100.00 chemokine 22 39.76 iatrogenic 1 29.20 Bioavailability 3 5.00 cytokine 2 5.00 headache 2 5.00 Potency 2 5.00 Parenteral administration 1 5.00 Inflammation 1 5.00 agonist 1 5.00

Disease Link Frequency Relevance Heat Lymphatic System Cancer 1 89.92 Adenocarcinoma 1 88.96 Acquired Immune Deficiency Syndrome Or Hiv Infection 72 80.24 Immunodeficiency 3 65.60 Infection 21 21.12 Sprains And Strains 11 5.00 Disease 4 5.00 Hepatotoxicity 3 5.00 Hepatitis 2 5.00 Yersinia Infection 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This finding has generated interest in the possibility that maraviroc, or CCR5 antagonists in general, may have an effect on elevating CD4 cell counts independent of antiviral activity.

CCR5 Regulation (effect) of CD4 associated with antagonist

1) Confidence 0.21 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504054 Disease Relevance 0.39 Pain Relevance 0.11

General Comments

This test has worked.