INT241750

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.18
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 5.72
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD4, ITIH4) signal transduction (CD4) extracellular region (ITIH4)
cell adhesion (CD4) enzyme binding (CD4) cytoplasm (ITIH4)
Anatomy Link Frequency
brain 2
covering 1
T-lymphocytes 1
CD4 (Homo sapiens)
ITIH4 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 344 100.00 Very High Very High Very High
chemokine 114 96.44 Very High Very High Very High
antagonist 165 95.00 High High
Potency 37 79.20 Quite High
rheumatoid arthritis 4 79.20 Quite High
Central nervous system 50 29.20 Quite Low
anesthesia 7 8.88 Low Low
Bioavailability 14 5.00 Very Low Very Low Very Low
headache 10 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 448 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 772 99.98 Very High Very High Very High
Viral Infection 8 99.38 Very High Very High Very High
Immunodeficiency 21 99.28 Very High Very High Very High
Encephalopathy 4 85.76 High High
Hepatitis 8 80.20 Quite High
Rheumatoid Arthritis 4 79.20 Quite High
Syndrome 9 74.40 Quite High
Pox Virus Infection 11 63.04 Quite High
Death 1 61.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Amos Smith (University of Pennsylvania), is an entry inhibitor that has been proposed to function through inhibition of CD4 binding [79,80]; however, other evidences indicate that it may bind to unliganded gp120 and target the CD4-induced conformational re-arrangement of gp120 and gp41 [81,82].
CD4 Binding (arrangement) of gp120
1) Confidence 0.18 Published 2008 Journal Retrovirology Section Body Doc Link PMC2576352 Disease Relevance 0.08 Pain Relevance 0
The gp120's C2 region asparagine 283 (N283) has been previously associated with macrophage tropism, brain infection, lower CD4 dependence and higher CD4 affinity.
CD4 Binding (associated) of gp120 in brain associated with addiction and infection
2) Confidence 0.17 Published 2008 Journal Retrovirology Section Abstract Doc Link PMC2576352 Disease Relevance 0.17 Pain Relevance 0.24
Structural analysis of unliganded gp120 from the related simian immunodeficiency virus has suggested that the large gp120 region involved in binding to CD4, the CD4-binding site (CD4bs), may only form a stable, binding-competent conformation when gp120 actually engages CD4 [1].
CD4 Binding (binding) of gp120 associated with immunodeficiency
3) Confidence 0.17 Published 2008 Journal Retrovirology Section Body Doc Link PMC2576352 Disease Relevance 0.37 Pain Relevance 0.07
The gp120's C2 region asparagine 283 (N283) has been previously associated with macrophage tropism, brain infection, lower CD4 dependence and higher CD4 affinity.
CD4 Binding (associated) of gp120 in brain associated with addiction and infection
4) Confidence 0.17 Published 2008 Journal Retrovirology Section Abstract Doc Link PMC2576352 Disease Relevance 0.17 Pain Relevance 0.24
Structural analysis of unliganded gp120 from the related simian immunodeficiency virus has suggested that the large gp120 region involved in binding to CD4, the CD4-binding site (CD4bs), may only form a stable, binding-competent conformation when gp120 actually engages CD4 [1].
CD4 Binding (engages) of gp120 associated with immunodeficiency
5) Confidence 0.17 Published 2008 Journal Retrovirology Section Body Doc Link PMC2576352 Disease Relevance 0.25 Pain Relevance 0.10
The interaction with CD4 triggers a rather large conformational change in gp120 that results in the formation and/or exposure of highly conserved regions previously folded into the core structure and/or sheltered by the variable loops and the glycans covering the outer domain of gp120 [2-9].
CD4 Binding (interaction) of gp120 in covering
6) Confidence 0.16 Published 2008 Journal Retrovirology Section Body Doc Link PMC2576352 Disease Relevance 0.24 Pain Relevance 0.11
Hosahudya Gopi and Irwin Chaiken, Drexel University College of Medicine) was generated by click conjugation and functions as an entry inhibitor since it prevents viral infection and has been shown to inhibit interactions of both monomeric and trimeric soluble gp120 with soluble CD4 [83-86].
CD4 Binding (interactions) of gp120 associated with viral infection
7) Confidence 0.15 Published 2008 Journal Retrovirology Section Body Doc Link PMC2576352 Disease Relevance 0.17 Pain Relevance 0
Blocking the gp120 interaction with CD4 by a small molecule BMS-378806 protected most macaques from vaginal SHIV challenge, verifying that the CD4-envelope interaction is a possible target for a microbicide [25].
CD4 Binding (interaction) of gp120
8) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929209 Disease Relevance 0.18 Pain Relevance 0
HIV gp120 binds to the CD4 receptor on the surface of T-lymphocytes, and the cell surface proteins CCR5 or CXCR4 act as coreceptors for viral attachment (Chan and Kim 1998).
CD4 Binding (binds) of gp120 in T-lymphocytes associated with acquired immune deficiency syndrome or hiv infection
9) Confidence 0.11 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504066 Disease Relevance 0.85 Pain Relevance 0.13
These include agents to block CD4 binding by viral gp120, inhibit CCR5 or CXCR4 co-receptor binding by gp120, as well as inhibit gp41 mediated fusion of the viral and cellular lipid bilayers as the Food and Drug Administration (FDA)-approved agent enfuvirtide does (Guo et al 2003; Jacobson et al 2004; Oldfield et al 2005; Kadow et al 2006; Moyle et al 2007).
CD4 Binding (binding) of gp120
10) Confidence 0.07 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504054 Disease Relevance 0.71 Pain Relevance 0.04
On exposure of the virus to a cell expressing CD4, gp120 interacts with the CD4 molecule, thereby inducing a conformational change in gp120 that enables binding to the chemokine receptor (see Figure 1).
CD4 Binding (interacts) of gp120 associated with chemokine
11) Confidence 0.06 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504054 Disease Relevance 0.54 Pain Relevance 0.16
Gp120 associates with the CD4 receptor on the surface of the host cell; gp41 spans the viral envelope and mediates viral fusion with the host cell.
CD4 receptor Binding (associates) of Gp120
12) Confidence 0.06 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504054 Disease Relevance 0.89 Pain Relevance 0.17
On exposure of the virus to a cell expressing CD4, gp120 interacts with the CD4 molecule, thereby inducing a conformational change in gp120 that enables binding to the chemokine receptor (see Figure 1).
CD4 Binding (interacts) of gp120 associated with chemokine
13) Confidence 0.06 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504054 Disease Relevance 0.54 Pain Relevance 0.16
There are several compounds in development that inhibit the initial interaction between gp120 and the CD4 receptor.
CD4 receptor Neg (inhibit) Binding (interaction) of gp120
14) Confidence 0.06 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012555 Disease Relevance 0.54 Pain Relevance 0.13

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox