INT241751

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Context Info
Confidence 0.18
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.07
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD4, ITIH4) signal transduction (CD4) extracellular region (ITIH4)
cell adhesion (CD4) enzyme binding (CD4) cytoplasm (ITIH4)
CD4 (Homo sapiens)
ITIH4 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 1 79.44 Quite High
addiction 49 50.00 Quite Low
chemokine 25 43.12 Quite Low
antagonist 34 5.00 Very Low Very Low Very Low
Central nervous system 7 5.00 Very Low Very Low Very Low
Potency 6 5.00 Very Low Very Low Very Low
Bioavailability 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Viral Infection 1 99.54 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 130 97.52 Very High Very High Very High
Encephalopathy 1 86.00 High High
Infection 84 80.92 Quite High
Hepatitis 2 80.44 Quite High
Rheumatoid Arthritis 1 79.44 Quite High
Pox Virus Infection 2 63.28 Quite High
Yersinia Infection 2 61.04 Quite High
Disease 6 31.56 Quite Low
Sprains And Strains 14 13.68 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hosahudya Gopi and Irwin Chaiken, Drexel University College of Medicine) was generated by click conjugation and functions as an entry inhibitor since it prevents viral infection and has been shown to inhibit interactions of both monomeric and trimeric soluble gp120 with soluble CD4 [83-86].
Negative_regulation (inhibit) of CD4 Binding (interactions) of gp120 associated with viral infection
1) Confidence 0.18 Published 2008 Journal Retrovirology Section Body Doc Link PMC2576352 Disease Relevance 0.17 Pain Relevance 0
Blocking the gp120 interaction with CD4 by a small molecule BMS-378806 protected most macaques from vaginal SHIV challenge, verifying that the CD4-envelope interaction is a possible target for a microbicide [25].
Negative_regulation (Blocking) of CD4 Binding (interaction) of gp120
2) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929209 Disease Relevance 0.18 Pain Relevance 0
These include agents to block CD4 binding by viral gp120, inhibit CCR5 or CXCR4 co-receptor binding by gp120, as well as inhibit gp41 mediated fusion of the viral and cellular lipid bilayers as the Food and Drug Administration (FDA)-approved agent enfuvirtide does (Guo et al 2003; Jacobson et al 2004; Oldfield et al 2005; Kadow et al 2006; Moyle et al 2007).
Negative_regulation (block) of CD4 Binding (binding) of gp120
3) Confidence 0.07 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504054 Disease Relevance 0.72 Pain Relevance 0.04

General Comments

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