INT241752

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.71
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ITIH4, CXCR4) cytoplasm (ITIH4, CXCR4) extracellular region (ITIH4)
cytoplasmic membrane-bounded vesicle (CXCR4) signal transducer activity (CXCR4)
ITIH4 (Homo sapiens)
CXCR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 1 78.08 Quite High
chemokine 22 47.28 Quite Low
antagonist 32 5.00 Very Low Very Low Very Low
Bioavailability 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
iatrogenic 1 5.00 Very Low Very Low Very Low
Parenteral administration 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 72 96.16 Very High Very High Very High
Encephalopathy 1 84.64 Quite High
Infection 21 79.56 Quite High
Hepatitis 2 79.08 Quite High
Rheumatoid Arthritis 1 78.08 Quite High
Pox Virus Infection 1 61.92 Quite High
Yersinia Infection 2 59.68 Quite High
Disease 4 30.20 Quite Low
Sprains And Strains 11 5.00 Very Low Very Low Very Low
Immunodeficiency 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These include agents to block CD4 binding by viral gp120, inhibit CCR5 or CXCR4 co-receptor binding by gp120, as well as inhibit gp41 mediated fusion of the viral and cellular lipid bilayers as the Food and Drug Administration (FDA)-approved agent enfuvirtide does (Guo et al 2003; Jacobson et al 2004; Oldfield et al 2005; Kadow et al 2006; Moyle et al 2007).
gp120 Negative_regulation (inhibit) of CXCR4 Binding (co-receptor binding) of
1) Confidence 0.08 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504054 Disease Relevance 0.71 Pain Relevance 0.04

General Comments

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