INT241764

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Context Info
Confidence 0.27
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.95
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Shbg) extracellular region (Shbg)
Shbg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
headache 1 37.12 Quite Low
cva 2 8.88 Low Low
imagery 2 6.72 Low Low
tolerance 6 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Migraine 1 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertension 54 98.02 Very High Very High Very High
Polycystic Ovary Syndrome 55 95.24 Very High Very High Very High
Hirsutism 44 94.48 High High
Hyperandrogenism 9 86.32 High High
Metabolic Syndrome 2 76.76 Quite High
Weight Loss 1 74.72 Quite High
Obesity 8 73.96 Quite High
Rheumatoid Arthritis 6 70.48 Quite High
Cardiovascular Disease 5 59.04 Quite High
Metrorrhagia 1 45.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This indicates that the increase in SHBG occurs soon after the administration of the drospirenone-containing COC and that it is a long-lasting rather than transient effect.
Positive_regulation (occurs) of Positive_regulation (increase) of SHBG
1) Confidence 0.27 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504056 Disease Relevance 0.61 Pain Relevance 0
The most important findings were as follows: the increase in SBP during resistance exercise was greater in hypertensive vs. normotensive subjects; in hypertensive and normotensive subjects alike, low-intensity resistance exercise, when performed to exhaustion, induced an increase in SBP greater than that induced by high-intensity resistance exercise; and BP recovery during the rest periods between exercise sets was impaired in hypertensive subjects.
Positive_regulation (induced) of Positive_regulation (increase) of SBP associated with hypertension
2) Confidence 0.16 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2845767 Disease Relevance 0.64 Pain Relevance 0
reducing gonadotropin secretion and thereby reducing ovarian androgen production.[18]increasing levels of SHBG resulting in lower levels of free testosterone.inhibiting adrenal androgen production.[19]

Androgen receptor blockers

Positive_regulation (resulting) of Positive_regulation (increasing) of SHBG
3) Confidence 0.10 Published 2010 Journal Indian Journal of Dermatology Section Body Doc Link PMC2856356 Disease Relevance 0.70 Pain Relevance 0

General Comments

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