INT241775

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.17
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (AVP, AQP2) aging (AQP2) protein complex (AQP2)
cytoplasm (AQP2) cell-cell signaling (AVP) response to stress (AVP)
Anatomy Link Frequency
collecting tubules 2
AVP (Homo sapiens)
AQP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
medulla 1 39.08 Quite Low
adenocard 1 14.44 Low Low
antagonist 21 5.00 Very Low Very Low Very Low
anticonvulsant 2 5.00 Very Low Very Low Very Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
tricyclic antidepressant 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Nicotine 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Versed 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyponatremia 62 63.76 Quite High
Pressure And Volume Under Development 9 53.60 Quite High
Pressure Volume 2 Under Development 12 47.44 Quite Low
Heart Rate Under Development 24 19.92 Low Low
Myocardial Infarction 16 5.00 Very Low Very Low Very Low
Cirrhosis 9 5.00 Very Low Very Low Very Low
Vomiting 6 5.00 Very Low Very Low Very Low
Polycystic Kidney Disease 6 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 5 5.00 Very Low Very Low Very Low
Hypokalemia 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the presence of AVP and an intact hypertonic medullary interstitium, AVP, mediated by V2 receptors, upregulates the expression and trafficking of aquaporin-2 to the luminal side of the collecting tubules and allows water to be reabsorbed efficiently into a more tonic medullary milieu.
AVP Positive_regulation (upregulates) of Gene_expression (expression) of aquaporin-2 in collecting tubules
1) Confidence 0.08 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504060 Disease Relevance 0.17 Pain Relevance 0

General Comments

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