INT241777

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.75
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (AVP) cell-cell signaling (AVP) response to stress (AVP)
signal transducer activity (AVP) cytosol (AVP) extracellular space (AVP)
Anatomy Link Frequency
reticulum 2
AVP (Homo sapiens)
TRGV9 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 21 89.52 High High
fibrosis 1 85.92 High High
headache 1 24.32 Low Low
anticonvulsant 2 5.00 Very Low Very Low Very Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
tricyclic antidepressant 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Nicotine 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Versed 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nephrogenic Diabetes Insipidus 3 94.04 High High
Internal Fibrosis 1 85.92 High High
Cyst 2 84.84 Quite High
Polycystic Kidney Disease 6 81.28 Quite High
Autosomal Recessive Polycystic Kidney 1 51.36 Quite High
Hyponatremia 62 50.00 Quite Low
Pressure And Volume Under Development 9 41.84 Quite Low
Renal Disease 1 38.32 Quite Low
Increased Venous Pressure Under Development 5 25.20 Quite Low
Headache 1 24.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The pathogenic mechanisms may involve mutations leading to reduced AVP binding to V2 receptors (type 1), misfolding hence reduced trafficking of V2 receptors from the endoplasmic reticulum to cell surface (type 2), or direct defect in the transcription of V2 receptors (type 3) (Fujiwara and Bichet 2005).
Negative_regulation (reduced) of AVP Binding (binding) of V2 in reticulum
1) Confidence 0.10 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504060 Disease Relevance 0.75 Pain Relevance 0.13

General Comments

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