INT241787

Context Info Confidence 0.57 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.38 Pain Relevance 0.03

aging (AQP2) plasma membrane (AQP2) protein complex (AQP2) transmembrane transport (AQP2) lysosome (AQP2) cytoplasm (AQP2)

Anatomy Link Frequency collecting tubules 1 AQP2 (Homo sapiens)

Pain Link Frequency Relevance Heat antagonist 21 56.72 anticonvulsant 2 5.00 Neuropeptide 2 5.00 tricyclic antidepressant 2 5.00 Pain 2 5.00 Nicotine 1 5.00 Bioavailability 1 5.00 Versed 1 5.00 medulla 1 5.00 withdrawal 1 5.00

Disease Link Frequency Relevance Heat Hyponatremia 62 97.96 Manic Depressive Disorder 1 93.08 Nephrotoxicity 1 92.48 Renal Failure 1 88.28 Cirrhosis 9 87.56 Vomiting 6 84.84 Sunburn 1 84.36 Uremia 1 83.64 Volume Depletion And Dehydration 2 72.72 Pressure Volume 2 Under Development 12 57.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The mechanism of action is thought to be via the downregulation aquaporin 2 in collecting tubules (Robbenet al 2006).

Negative_regulation (downregulation) of aquaporin 2 in collecting tubules

1) Confidence 0.57 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504060 Disease Relevance 1.38 Pain Relevance 0.03

General Comments

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