INT241787

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Context Info
Confidence 0.57
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.38
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (AQP2) plasma membrane (AQP2) protein complex (AQP2)
transmembrane transport (AQP2) lysosome (AQP2) cytoplasm (AQP2)
Anatomy Link Frequency
collecting tubules 1
AQP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 21 56.72 Quite High
anticonvulsant 2 5.00 Very Low Very Low Very Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
tricyclic antidepressant 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Nicotine 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Versed 1 5.00 Very Low Very Low Very Low
medulla 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyponatremia 62 97.96 Very High Very High Very High
Manic Depressive Disorder 1 93.08 High High
Nephrotoxicity 1 92.48 High High
Renal Failure 1 88.28 High High
Cirrhosis 9 87.56 High High
Vomiting 6 84.84 Quite High
Sunburn 1 84.36 Quite High
Uremia 1 83.64 Quite High
Volume Depletion And Dehydration 2 72.72 Quite High
Pressure Volume 2 Under Development 12 57.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mechanism of action is thought to be via the downregulation aquaporin 2 in collecting tubules (Robbenet al 2006).
Negative_regulation (downregulation) of aquaporin 2 in collecting tubules
1) Confidence 0.57 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504060 Disease Relevance 1.38 Pain Relevance 0.03

General Comments

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