INT241788

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Context Info
Confidence 0.67
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.26
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (AQP2) plasma membrane (AQP2) protein complex (AQP2)
transmembrane transport (AQP2) lysosome (AQP2) cytoplasm (AQP2)
Anatomy Link Frequency
duct 2
AQP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 2 96.72 Very High Very High Very High
adenocard 1 96.04 Very High Very High Very High
carbamazepine 22 90.48 High High
medulla 1 64.72 Quite High
sSRI 6 63.20 Quite High
Trigeminal neuralgia 4 59.28 Quite High
neuralgia 1 56.08 Quite High
Pain 6 53.80 Quite High
anticonvulsant 2 50.24 Quite High
tricyclic antidepressant 2 49.56 Quite Low
Disease Link Frequency Relevance Heat
Hyponatremia 135 97.60 Very High Very High Very High
Increased Venous Pressure Under Development 5 80.24 Quite High
Myocardial Infarction 16 79.40 Quite High
Pressure And Volume Under Development 21 78.80 Quite High
Depression 3 70.36 Quite High
Headache 11 59.28 Quite High
Neuralgia 1 56.08 Quite High
Hypoglycemia 1 54.52 Quite High
Pain 6 53.80 Quite High
Vomiting 11 53.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Instead, a 40% increase in the expression of the water channel aquaporin-2 water in the renal collecting duct was shown, suggesting a direct renal effect of the drug.
Positive_regulation (increase) of Gene_expression (expression) of water channel aquaporin-2 in duct
1) Confidence 0.67 Published 2009 Journal NDT Plus Section Body Doc Link PMC2762828 Disease Relevance 0.81 Pain Relevance 0.54
The subgroup of aquaporins is composed of AQP0, AQP1, AQP2, AQP4, AQP5, AQP6 and AQP8 and is considered to be mainly permeable to water with a high flow rate.
Positive_regulation (subgroup) of Gene_expression (composed) of AQP2
2) Confidence 0.20 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923373 Disease Relevance 0 Pain Relevance 0
The down-stream effect is enhanced production and trafficking of the water channels aquaporin-2 to the luminal membranes to facilitate water reabsorption into the hypertonic medullary interstitium.
Positive_regulation (enhanced) of Gene_expression (production) of aquaporin-2
3) Confidence 0.07 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504060 Disease Relevance 0.45 Pain Relevance 0.16

General Comments

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