INT241788

Context Info Confidence 0.67 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.26 Pain Relevance 0.70

aging (AQP2) plasma membrane (AQP2) protein complex (AQP2) transmembrane transport (AQP2) lysosome (AQP2) cytoplasm (AQP2)

Anatomy Link Frequency duct 2 AQP2 (Homo sapiens)

Pain Link Frequency Relevance Heat fluoxetine 2 96.72 adenocard 1 96.04 carbamazepine 22 90.48 medulla 1 64.72 sSRI 6 63.20 Trigeminal neuralgia 4 59.28 neuralgia 1 56.08 Pain 6 53.80 anticonvulsant 2 50.24 tricyclic antidepressant 2 49.56

Disease Link Frequency Relevance Heat Hyponatremia 135 97.60 Increased Venous Pressure Under Development 5 80.24 Myocardial Infarction 16 79.40 Pressure And Volume Under Development 21 78.80 Depression 3 70.36 Headache 11 59.28 Neuralgia 1 56.08 Hypoglycemia 1 54.52 Pain 6 53.80 Vomiting 11 53.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Instead, a 40% increase in the expression of the water channel aquaporin-2 water in the renal collecting duct was shown, suggesting a direct renal effect of the drug.

Positive_regulation (increase) of Gene_expression (expression) of water channel aquaporin-2 in duct

1) Confidence 0.67 Published 2009 Journal NDT Plus Section Body Doc Link PMC2762828 Disease Relevance 0.81 Pain Relevance 0.54

The subgroup of aquaporins is composed of AQP0, AQP1, AQP2, AQP4, AQP5, AQP6 and AQP8 and is considered to be mainly permeable to water with a high flow rate.

Positive_regulation (subgroup) of Gene_expression (composed) of AQP2

2) Confidence 0.20 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923373 Disease Relevance 0 Pain Relevance 0

The down-stream effect is enhanced production and trafficking of the water channels aquaporin-2 to the luminal membranes to facilitate water reabsorption into the hypertonic medullary interstitium.

Positive_regulation (enhanced) of Gene_expression (production) of aquaporin-2

3) Confidence 0.07 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504060 Disease Relevance 0.45 Pain Relevance 0.16

General Comments

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