INT241800

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.05
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (GBA) hydrolase activity, acting on glycosyl bonds (GBA) cell death (GBA)
carbohydrate metabolic process (GBA) lipid metabolic process (GBA)
Anatomy Link Frequency
lateral 2
GBA (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 7 82.20 Quite High
magnetoencephalography 5 74.92 Quite High
Neuropathic pain 1 50.68 Quite High
peripheral neuropathy 6 5.00 Very Low Very Low Very Low
primary somatosensory cortex 3 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Paresthesia 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Thalamus 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Gauchers Disease 31 99.26 Very High Very High Very High
Tinnitus 47 88.00 High High
Pain 6 82.20 Quite High
Arrhythmia Under Development 2 76.32 Quite High
Deafness 4 68.88 Quite High
Death 2 50.80 Quite High
Neuropathic Pain 1 50.68 Quite High
Neurologic Manifestations 4 47.56 Quite Low
Disease 3 43.60 Quite Low
Fabry Disease 1 36.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As a result, GABAa mediated lateral inhibition is reduced, inducing a surrounding coupled gamma band activity (GBA) known as the “edge effect” [9], [11].
Negative_regulation (reduced) of Positive_regulation (inducing) of GBA in lateral
1) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754613 Disease Relevance 0.72 Pain Relevance 0.24
The efficacy of miglustat in Gaucher disease type I probably results from both a decrease in the biosynthesis of GlcCer and an increase in the activity of glucocerebrosidase.


Negative_regulation (decrease) of Positive_regulation (increase) of glucocerebrosidase associated with gauchers disease
2) Confidence 0.21 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504062 Disease Relevance 0.32 Pain Relevance 0

General Comments

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