INT241802

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.27
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (GBA) hydrolase activity, acting on glycosyl bonds (GBA) cell death (GBA)
carbohydrate metabolic process (GBA) lipid metabolic process (GBA)
GBA (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 11 95.72 Very High Very High Very High
Inflammation 12 5.00 Very Low Very Low Very Low
peripheral neuropathy 8 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Calcium channel 2 5.00 Very Low Very Low Very Low
Paresthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Gauchers Disease 167 99.92 Very High Very High Very High
Neurological Disease 4 86.36 High High
Hepatomegaly 2 83.00 Quite High
Splenomegaly 6 82.44 Quite High
Thrombocytopenia 3 69.12 Quite High
Anaemia 3 68.40 Quite High
Neurologic Manifestations 8 60.88 Quite High
Lysosome Storage Disease 5 48.88 Quite Low
Hypersensitivity 1 48.80 Quite Low
Disease 33 47.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The gene encoding GC (GBA, MIM# 606463) and its homologous pseudogene are located on chromosome 1q21.2 To date, more than 250 different GBA mutations, including missense, nonsense, insertions or deletions that lead to frameshift or in-frame alterations, and splice junction mutations have been identified.
Regulation (located) of GBA
1) Confidence 0.39 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2909498 Disease Relevance 0.60 Pain Relevance 0.13
The gene encoding GC (GBA, MIM# 606463) and its homologous pseudogene are located on chromosome 1q21.2 To date, more than 250 different GBA mutations, including missense, nonsense, insertions or deletions that lead to frameshift or in-frame alterations, and splice junction mutations have been identified.
Regulation (located) of GBA
2) Confidence 0.39 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2909498 Disease Relevance 0.59 Pain Relevance 0.13
Imiglucerase is a modified form of glucocerebrosidase, created using recombinant DNA technology, and is given as intravenous infusions, usually every other week.
Regulation (modified) of Imiglucerase
3) Confidence 0.13 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504062 Disease Relevance 1.08 Pain Relevance 0.04

General Comments

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